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TFPI: tissue factor pathway inhibitor

1 protein, 200 patents, 4 drugs, 16 trials, 2,881 NIH grants and 6,428 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTFPIHGNC
Nametissue factor pathway inhibitorHGNC
NCBI Gene ID7035NCBI Gene
HGNC IDHGNC:11760HGNC
EnsemblENSG00000003436NCBI Gene
AliasesEPI, LACI, TFI, TFPI1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P10646Tissue factor pathway inhibitor3049Ensembl, GeneID, HGNCUniProt

Patents 200

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4825396 A12026-10-2113P10646Espacenet
EP 4752550 A22026-06-031P10646Espacenet
JP 2026004568 A2026-01-1467155P10646Espacenet
JP 2026004568 A2026-01-1467157P10646Espacenet
EP 4650780 A22025-11-19848P10646Espacenet
JP 2025147176 A2025-10-0613141P10646Espacenet
JP 2025147176 A2025-10-0613142P10646Espacenet
JP 2025529142 A2025-09-047867P10646Espacenet
WO 2025177003 A12025-08-281P10646Espacenet
JP 2025124816 A2025-08-261P10646Espacenet

Drugs 4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ANDEXANET ALFACHEMBL3301583Tissue factor pathway inhibitor inhibitorINHIBITORChEMBL
BAY-1093884CHEMBL4297904Tissue factor pathway inhibitor inhibitorINHIBITORChEMBL
CONCIZUMABCHEMBL4297730Tissue factor pathway inhibitor inhibitorINHIBITORChEMBL
MARSTACIMABCHEMBL3990039Tissue factor pathway inhibitor inhibitorINHIBITORChEMBL

Trials 16

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07161687MARSTACIMABClinicalTrials.gov
NCT06992076MARSTACIMABClinicalTrials.gov
NCT06831734CONCIZUMABClinicalTrials.gov
NCT06703606MARSTACIMABPHASE1ClinicalTrials.gov
NCT05898412ANDEXANET ALFAClinicalTrials.gov
NCT05548777ANDEXANET ALFAClinicalTrials.gov
NCT04878731MARSTACIMABPHASE12023-07-07ClinicalTrials.gov
NCT03996486BAY-1093884PHASE1ClinicalTrials.gov
NCT03938792MARSTACIMABPHASE3ClinicalTrials.gov
NCT03597022BAY-1093884PHASE22020-11-30ClinicalTrials.gov

NIH grants 2881

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01HL068835Characterization of an isoform specific anticoagulant function of TFPI-alpha422,025NIH's project files
R01HL101972Characterization of Coagulation Factor-platelet Interactions: Role of FXI132,025NIH's project files
P30CA008748Cancer Center Support Grant92,025NIH's project files
P01HL139420Hemostasis and Thrombosis: Chemistry, Biology and Physiology82,025NIH's project files
ZIAHD002400The Role Of Subclinical Infection And Cytokines In Preterm Parturition82,025NIH's project files
P01AI045897A Tolerance Approach to Xenotransplantation72,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award72,025NIH's project files
ZIAAI000810Vector-Borne Diseases: Biology Of Vector Host Relationship72,025NIH's project files
P30CA016672Cancer Center Support Grant62,025NIH's project files
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)62,025NIH's project files

Papers 6428

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42808109PubTator, text miningPubMed
42773271PubTator, text miningPubMed
42757060PubTator, text miningPubMed
42721217PubTator, text miningPubMed
42698050PubTator, text miningPubMed
42676001PubTator, text miningPubMed
42648366PubTator, text miningPubMed
42648365PubTator, text miningPubMed
42631549PubTator, text miningPubMed
42567407PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license