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TGFA: transforming growth factor alpha

1 protein, 116 patents, 1 drug, 5 trials, 6,441 NIH grants and 12,091 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTGFAHGNC
Nametransforming growth factor alphaHGNC
NCBI Gene ID7039NCBI Gene
HGNC IDHGNC:11765HGNC
EnsemblENSG00000163235NCBI Gene
AliasesTFGANCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P01135Protransforming growth factor alpha16011Ensembl, GeneID, HGNCUniProt

Patents 116

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026034588 A2026-02-2722P01135Espacenet
JP 2026004467 A2026-01-1422P01135Espacenet
JP 2026004568 A2026-01-1467504P01135Espacenet
JP 2025179064 A2025-12-09194P01135Espacenet
EP 4650780 A22025-11-193612P01135Espacenet
EP 4626486 A22025-10-0825P01135Espacenet
JP 2025529142 A2025-09-044654P01135Espacenet
US 12371689 B22025-07-294654P01135Espacenet
US 12351822 B22025-07-0822P01135Espacenet
JP 2025517970 A2025-06-123612P01135Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
FEPIXNEBARTCHEMBL4594573Protransforming growth factor alpha inhibitorINHIBITORChEMBL

Trials 5

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05986292FEPIXNEBARTPHASE2ClinicalTrials.gov
NCT04529096FEPIXNEBARTPHASE22022-06-23ClinicalTrials.gov
NCT04476108FEPIXNEBARTPHASE22022-08-03ClinicalTrials.gov
NCT04456686FEPIXNEBARTPHASE22022-06-23ClinicalTrials.gov
NCT01774981FEPIXNEBARTPHASE1/PHASE22017-08-15ClinicalTrials.gov

NIH grants 6441

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant792,025NIH's project files
P30CA068485Cancer Center Support Grant322,025NIH's project files
P30CA008748Cancer Center Support Grant272,025NIH's project files
P50CA097190Head and Neck Cancer SPORE262,025NIH's project files
ZIABC011028Clinical Studies of the Molecular Genetic Basis of Kidney Cancer142,025NIH's project files
ZIABC011038Molecular Therapeutics of Kidney Cancer: VHL Gene and Fumarate Hydratase Gene142,025NIH's project files
P30CA014520UW Comprehensive Cancer Center Support132,025NIH's project files
P30CA016058Cancer Center Support Grant132,025NIH's project files
P30DK058404Molecular and Cellular Basis for Digestive Diseases132,025NIH's project files
P30CA006973Regional Oncology Research Center122,025NIH's project files

Papers 12091

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42791438PubTator, text miningPubMed
42730912PubTator, text miningPubMed
42695881PubTator, text miningPubMed
42679142PubTator, text miningPubMed
42674883PubTator, text miningPubMed
42668568PubTator, text miningPubMed
42650831PubTator, text miningPubMed
42640037PubTator, text miningPubMed
42630718PubTator, text miningPubMed
42588699PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license