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TGFB1: transforming growth factor beta 1

1 protein, 245 patents, 5 drugs, 111 trials, 49,789 NIH grants and 225,278 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTGFB1HGNC
Nametransforming growth factor beta 1HGNC
NCBI Gene ID7040NCBI Gene
HGNC IDHGNC:11766HGNC
EnsemblENSG00000105329NCBI Gene
AliasesCAEND1, CED, DPD1, IBDIMDE, LAP, TGF-beta1, TGFB, TGFbetaNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P01137Transforming growth factor beta-1 proprotein39021Ensembl, GeneID, HGNCUniProt

Patents 245

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026167214 A12026-08-1390P01137Espacenet
JP 2026517896 A2026-06-0253P01137Espacenet
JP 2026082951 A2026-05-191P01137Espacenet
JP 2026031518 A2026-02-2494P01137Espacenet
WO 2026022479 A12026-01-296P01137Espacenet
US 12528850 B22026-01-20106P01137Espacenet
JP 2025186460 A2025-12-2368P01137Espacenet
EP 4662245 A12025-12-1794P01137Espacenet
EP 4650780 A22025-11-19529P01137Espacenet
JP 2025169942 A2025-11-141327P01137Espacenet

Drugs 5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BINTRAFUSP ALFACHEMBL4298024Transforming growth factor beta binding agentBINDING AGENTChEMBL
FRESOLIMUMABCHEMBL1743022Transforming growth factor beta-1 inhibitorINHIBITORChEMBL
LUSPATERCEPTCHEMBL3039545Transforming growth factor beta inhibitorINHIBITORChEMBL
LY-2382770CHEMBL2109585Transforming growth factor beta-1 inhibitorINHIBITORChEMBL
METELIMUMABCHEMBL2108431Transforming growth factor beta-1 inhibitorINHIBITORChEMBL

Trials 111

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07465029LUSPATERCEPTClinicalTrials.gov
NCT07463820LUSPATERCEPTPHASE2ClinicalTrials.gov
NCT07450313LUSPATERCEPTPHASE2ClinicalTrials.gov
NCT07362095LUSPATERCEPTPHASE1/PHASE2ClinicalTrials.gov
NCT07338344LUSPATERCEPTPHASE2ClinicalTrials.gov
NCT07331818LUSPATERCEPTPHASE2ClinicalTrials.gov
NCT07215975LUSPATERCEPTClinicalTrials.gov
NCT07096297LUSPATERCEPTPHASE2ClinicalTrials.gov
NCT07075406LUSPATERCEPTClinicalTrials.gov
NCT07073690LUSPATERCEPTClinicalTrials.gov

NIH grants 49789

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant6532,025NIH's project files
P30CA008748Cancer Center Support Grant5112,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award2072,025NIH's project files
P30CA068485Cancer Center Support Grant1782,025NIH's project files
P30CA006973Regional Oncology Research Center1722,025NIH's project files
P30CA016058Cancer Center Support Grant1602,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant1352,025NIH's project files
P30CA060553The Robert H. Lurie Comprehensive Cancer Center1312,025NIH's project files
P30CA047904Cancer Center Support Grant1262,025NIH's project files
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant1122,025NIH's project files

Papers 225278

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826860PubTator, text miningPubMed
42825916PubTator, text miningPubMed
42825382PubTator, text miningPubMed
42825366PubTator, text miningPubMed
42825353PubTator, text miningPubMed
42825329PubTator, text miningPubMed
42825098PubTator, text miningPubMed
42824591PubTator, text miningPubMed
42824291PubTator, text miningPubMed
42824116PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license