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TGFB2: transforming growth factor beta 2

1 protein, 247 patents, 5 drugs, 117 trials, 6,475 NIH grants and 13,404 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTGFB2HGNC
Nametransforming growth factor beta 2HGNC
NCBI Gene ID7042NCBI Gene
HGNC IDHGNC:11768HGNC
EnsemblENSG00000092969NCBI Gene
AliasesCAEND2, G-TSF, LDS4, TGF-beta2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P61812Transforming growth factor beta-2 proprotein41411Ensembl, GeneID, HGNCUniProt

Patents 247

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026086743 A2026-05-26194P61812Espacenet
JP 2026082951 A2026-05-1914P61812Espacenet
JP 2026511149 A2026-04-107255P61812Espacenet
EP 4705273 A22026-03-11191P61812Espacenet
JP 2026506884 A2026-02-2764P61812Espacenet
EP 4683651 A22026-01-287255P61812Espacenet
EP 4667578 A22025-12-24207P61812Espacenet
EP 4667578 A22025-12-24209P61812Espacenet
EP 4661887 A12025-12-1764P61812Espacenet
JP 2025538981 A2025-12-032P61812Espacenet

Drugs 5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BINTRAFUSP ALFACHEMBL4298024Transforming growth factor beta binding agentBINDING AGENTChEMBL
FRESOLIMUMABCHEMBL1743022Transforming growth factor beta-2 inhibitorINHIBITORChEMBL
LERDELIMUMABCHEMBL2108967Transforming growth factor beta-2 inhibitorINHIBITORChEMBL
LUSPATERCEPTCHEMBL3039545Transforming growth factor beta inhibitorINHIBITORChEMBL
TRABEDERSENCHEMBL2108345Transforming growth factor beta-2 mRNA antisense inhibitorANTISENSE INHIBITORChEMBL

Trials 117

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07465029LUSPATERCEPTClinicalTrials.gov
NCT07463820LUSPATERCEPTPHASE2ClinicalTrials.gov
NCT07450313LUSPATERCEPTPHASE2ClinicalTrials.gov
NCT07362095LUSPATERCEPTPHASE1/PHASE2ClinicalTrials.gov
NCT07338344LUSPATERCEPTPHASE2ClinicalTrials.gov
NCT07331818LUSPATERCEPTPHASE2ClinicalTrials.gov
NCT07215975LUSPATERCEPTClinicalTrials.gov
NCT07096297LUSPATERCEPTPHASE2ClinicalTrials.gov
NCT07075406LUSPATERCEPTClinicalTrials.gov
NCT07073690LUSPATERCEPTClinicalTrials.gov

NIH grants 6475

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant442,025NIH's project files
P30CA008748Cancer Center Support Grant302,025NIH's project files
P30EY005722Center Core Grant for Vision Research252,025NIH's project files
P30EY016665Core Grant for Vision Research252,025NIH's project files
P30EY025585NEI Center Core Grant for Vision Research212,025NIH's project files
P30CA006973Regional Oncology Research Center162,025NIH's project files
P30EY010572Ophthalmology Core Facility162,025NIH's project files
R01CA109182Functional Determinants of Metastatic Dormancy162,025NIH's project files
P30CA054174Mays Cancer Center at UT Health SA142,025NIH's project files
P30CA016058Cancer Center Support Grant132,025NIH's project files

Papers 13404

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825078PubTator, text miningPubMed
42821793PubTator, text miningPubMed
42815006PubTator, text miningPubMed
42804496PubTator, text miningPubMed
42796630PubTator, text miningPubMed
42792932PubTator, text miningPubMed
42789212PubTator, text miningPubMed
42784876PubTator, text miningPubMed
42781881PubTator, text miningPubMed
42766934PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license