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TGFBR1: transforming growth factor beta receptor 1

1 protein, 199 patents, 2 drugs, 42 trials, 6,549 NIH grants and 13,131 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTGFBR1HGNC
Nametransforming growth factor beta receptor 1HGNC
NCBI Gene ID7046NCBI Gene
HGNC IDHGNC:11772HGNC
EnsemblENSG00000106799NCBI Gene
AliasesAAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, TBR-i, TBRI, TGFR-1, tbetaR-INCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P36897TGF-beta receptor type-150345Ensembl, GeneID, HGNCUniProt

Patents 199

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4778535 A12026-07-2273P36897Espacenet
JP 2026120541 A2026-07-2231P36897Espacenet
JP 2026082857 A2026-05-1931P36897Espacenet
JP 2026511149 A2026-04-107257P36897Espacenet
JP 2026508210 A2026-03-1034P36897Espacenet
JP 2026506884 A2026-02-2768P36897Espacenet
EP 4698581 A12026-02-2510P36897Espacenet
EP 4683651 A22026-01-287257P36897Espacenet
US 12528850 B22026-01-20114P36897Espacenet
EP 4671269 A12025-12-3134P36897Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
GALUNISERTIBCHEMBL2364611TGF-beta receptor type I inhibitorINHIBITORChEMBL
VACTOSERTIBCHEMBL3260567TGF-beta receptor type I inhibitorINHIBITORChEMBL

Trials 42

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07321860GALUNISERTIBPHASE2/PHASE3ClinicalTrials.gov
NCT06219733VACTOSERTIBPHASE2ClinicalTrials.gov
NCT06044311VACTOSERTIBPHASE2ClinicalTrials.gov
NCT05700656GALUNISERTIBPHASE1/PHASE2ClinicalTrials.gov
NCT05588648VACTOSERTIBPHASE1/PHASE2ClinicalTrials.gov
NCT05436990VACTOSERTIBPHASE2ClinicalTrials.gov
NCT05400122VACTOSERTIBPHASE1ClinicalTrials.gov
NCT04893252VACTOSERTIBPHASE2ClinicalTrials.gov
NCT04656002VACTOSERTIBPHASE2ClinicalTrials.gov
NCT04605562GALUNISERTIBPHASE2ClinicalTrials.gov

NIH grants 6549

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant462,025NIH's project files
P30CA008748Cancer Center Support Grant432,025NIH's project files
P30CA068485Cancer Center Support Grant322,025NIH's project files
P30CA016058Cancer Center Support Grant282,025NIH's project files
P30CA054174Mays Cancer Center at UT Health SA242,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award202,025NIH's project files
P30CA060553The Robert H. Lurie Comprehensive Cancer Center172,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase152,025NIH's project files
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant142,025NIH's project files
P30CA006973Regional Oncology Research Center132,025NIH's project files

Papers 13131

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42811985PubTator, text miningPubMed
42808155PubTator, text miningPubMed
42804717PubTator, text miningPubMed
42792932PubTator, text miningPubMed
42782774PubTator, text miningPubMed
42762718PubTator, text miningPubMed
42759216PubTator, text miningPubMed
42750898PubTator, text miningPubMed
42746182PubTator, text miningPubMed
42733101PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license