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Gene · 7051

TGM1: transglutaminase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TGM1: transglutaminase 1. Genes, record 7051. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7051

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Gene

Symbol
TGM1
HGNC
Name
transglutaminase 1
HGNC
NCBI Gene ID
7051
NCBI Gene
HGNC ID
HGNC:11777
HGNC
Ensembl
ENSG00000092295
NCBI Gene
Aliases
ARCI1, ICR2, KTG, LI, LI1, TGASE, TGK
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P22735Protein-glutamine gamma-glutamyltransferase K8171Ensembl, GeneID, HGNC

Source UniProt

Patents29

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1467559P22735Espacenet
EP 4641201 A22025-10-29207P22735Espacenet
JP 2025517969 A2025-06-12207P22735Espacenet
US 11717547 B22023-08-085P22735Espacenet
US 11446398 B22022-09-2090222P22735Espacenet
JP 2022524081 A2022-04-27193193P22735Espacenet
US 11078247 B22021-08-0311512P22735Espacenet
US 10525090 B22020-01-075P22735Espacenet
WO 2019200163 A12019-10-175P22735Espacenet
JP 2019054813 A2019-04-11247994P22735Espacenet

1 to 10 of 29

See all 29 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants834

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTGM1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant72025
P30CA008748Cancer Center Support Grant52025
R01AR068392Genetics and Pathobiology of Disorders of Keratinization52025
P30CA068485Cancer Center Support Grant42025
P30CA134274UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANT42025
R01AR043799Mechanisms of Epidermal Homeostasis and Early Neoplasia42025
R01AR066530Regulators of epidermal growth and differentiation42025
UL1TR001863Yale Clinical and Translational Science Award42025
ZIACP010121Molecular Epidemiology Studies of Occupational and Environmental Exposures42025
I01BX004293CYP11A1-derived secosteroids as therapeutic agents in UVB induced skin cancer32025

1 to 10 of 834Source NIH's project files

See all 834 nih grants

Papers2,299

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Anoectochilus roxburghii extract alleviates inflammation and restores skin barrier function in vitro and in vivo.Fitoterapia202642800590PubTator, text miningPubMed
Genotypic and Phenotypic Profiles of Babies with Collodion Membrane in a Tertiary Care Center in Riyadh, Saudi Arabia.Dermatology202642766467PubTator, text miningPubMed
An efficient endogenous type I-E CRISPR-Cas genome-editing platform for producing transglutaminase in Streptomyces mobaraensis.Eng Microbiol202642740853PubTator, text miningPubMed
Cathepsin D as a central regulator of extracellular matrix remodeling in wound healing and chronic tissue pathologies.Tissue Barriers202642720228PubTator, text miningPubMed
Synergistic modification of soy protein isolate using transglutaminase and magnesium chloride: A sequential treatment strategy for dual allergenicity and digestibility benefits.Food Chem202642659966PubTator, text miningPubMed
Enzymatic double crosslinking strategy: remodeling of pea protein isolate hydrogels through transglutaminase and gelatin modification to redesign their functional properties.Food Res Int202642637363PubTator, text miningPubMed
Controlled thermal unfolding of soy protein isolate modulates transglutaminase-induced gelation and network structure of fish gelatin.Food Chem202642594647PubTator, text miningPubMed
Transglutaminase-mediated glycosylation of whey protein isolate with glucosamine: effects on structure, functional properties, and intestinal barrier function.Food Chem X202642569495PubTator, text miningPubMed
Modification of shrimp tropomyosin properties for improved functional performance: TGase modification and polyphenol-beta-glucan modification.Food Chem202642551156PubTator, text miningPubMed
Repetin Regulates Epidermal Barrier Homeostasis and Is Associated With Inflammatory Skin Diseases.Exp Dermatol202642544840PubTator, text miningPubMed

1 to 10 of 2,299

See all 2,299 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7051

GET https://conductscience.org/api/genes/v1/7051/patents?page=2