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TH: tyrosine hydroxylase

1 protein, 50 patents, 1 drug, 1 trial, 9,727 NIH grants and 26,571 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTHHGNC
Nametyrosine hydroxylaseHGNC
NCBI Gene ID7054NCBI Gene
HGNC IDHGNC:11782HGNC
EnsemblENSG00000180176NCBI Gene
AliasesDYT14, DYT5b, TYHNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P07101Tyrosine 3-monooxygenase5287Ensembl, GeneID, HGNCUniProt

Patents 50

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1468803P07101Espacenet
JP 2025118609 A2025-08-133P07101Espacenet
JP 2025032204 A2025-03-1137125P07101Espacenet
US 12156890 B22024-12-037P07101Espacenet
EP 4461818 A22024-11-1337125P07101Espacenet
JP 2024112982 A2024-08-214537P07101Espacenet
US 11976296 B22024-05-074P07101Espacenet
US 11866749 B22024-01-0954P07101Espacenet
JP 2023522980 A2023-06-0119P07101Espacenet
US 11654161 B22023-05-237P07101Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
METYROSINECHEMBL1200862Tyrosine 3-hydroxylase inhibitorINHIBITORChEMBL

Trials 1

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT01127503METYROSINEPHASE22018-05-08ClinicalTrials.gov

NIH grants 9727

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
ZIANS003034Biomarkers of Catecholaminergic Neurodegeneration342,025NIH's project files
R01ES010563Mechanisms of Manganese Neurotoxicity292,025NIH's project files
P30CA008748Cancer Center Support Grant272,025NIH's project files
R01ES007331Mechanisms of Methylmercury Induced Neuronal Toxicity242,025NIH's project files
P51OD011132Emory National Primate Research Center202,025NIH's project files
P51OD011106Wisconsin National Primate Research Center Support192,025NIH's project files
T32ES012870Graduate and Postdoctoral Training in Environmental Health Science and Toxicology162,025NIH's project files
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)142,025NIH's project files
P30ES019776HERCULES: Exposome Research Center142,025NIH's project files
R01DA007418The Dopamine Synapse and Associative Learning142,025NIH's project files

Papers 26571

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42818171PubTator, text miningPubMed
42805900PubTator, text miningPubMed
42779254PubTator, text miningPubMed
42759523PubTator, text miningPubMed
42751903PubTator, text miningPubMed
42750047PubTator, text miningPubMed
42746669PubTator, text miningPubMed
42726111PubTator, text miningPubMed
42724825PubTator, text miningPubMed
42716372PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license