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Gene · 7058

THBS2: thrombospondin 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. THBS2: thrombospondin 2. Genes, record 7058. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7058

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Gene

Symbol
THBS2
HGNC
Name
thrombospondin 2
HGNC
NCBI Gene ID
7058
NCBI Gene
HGNC ID
HGNC:11786
HGNC
Ensembl
ENSG00000186340
NCBI Gene
Aliases
EDSCLL3, TSP2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P35442Thrombospondin-21,1722Ensembl, GeneID, HGNC

Source UniProt

Patents79

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-198112P35442Espacenet
EP 4640849 A22025-10-291229P35442Espacenet
EP 4641201 A22025-10-298257P35442Espacenet
JP 2025147176 A2025-10-0613192P35442Espacenet
JP 2025147176 A2025-10-0613193P35442Espacenet
JP 2025529142 A2025-09-047877P35442Espacenet
EP 4606428 A22025-08-274P35442Espacenet
US 12371689 B22025-07-297877P35442Espacenet
JP 2025519096 A2025-06-241229P35442Espacenet
JP 2025517969 A2025-06-128257P35442Espacenet

1 to 10 of 79

See all 79 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,850

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTHBS2 papersNewest fiscal year
P30CA014520UW Comprehensive Cancer Center Support142025
P30EY016665Core Grant for Vision Research142025
P30CA008748Cancer Center Support Grant132025
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)72025
R01CA164719Anti-cancer vaccine targeting the host-parasite interface during fluke infection72025
P30CA016672Cancer Center Support Grant62025
R01HL076246Chemokines in healing myocardial infarction52025
U01CA200468Clinical Validation Center for Early Detection of Pancreatic Cancer52025
U01CA210240Pancreatic Cancer Detection Consortium52025
U10CA180821Alliance for Clinical Trials in Oncology Operations Center - GY11 Funded Extension52025

1 to 10 of 1,850Source NIH's project files

See all 1,850 nih grants

Papers3,211

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Reduced vascular function, ventilatory efficiency and exercise capacity in young adult electronic cigarette users.ERJ Open Res202642807821PubTator, text miningPubMed
The Role of Thrombospondin-2 in Myocardial Fibrosis.Drug Des Devel Ther202642787207PubTator, text miningPubMed
Circulating angiogenic and inflammatory biomarkers profiling in patients with hereditary hemorrhagic telangiectasia.Eur J Intern Med202642778431PubTator, text miningPubMed
Conserved hepatic RNA signatures across multiple cohorts reveal novel mechanistic clues for advanced fibrosis in human MASLD.Hepatol Commun202642748406PubTator, text miningPubMed
Markers of microvascular instability predict severity and survival in idiopathic pulmonary fibrosis.Thorax202642722423PubTator, text miningPubMed
Proteomic Profiling of Breast Implant Capsules: a Novel Approach for Studying Biocompatibility and Capsular Contracture.Aesthet Surg J202642717641PubTator, text miningPubMed
From sebocytes to skin engineering human sebaceous organoids within a reconstructed dermal matrix.Front Toxicol202642598348PubTator, text miningPubMed
Myofibroblastic CAF and Malignant Ductal Cell Crosstalk Drives Epithelial-Mesenchymal Transition and Progression in Pancreatic Ductal Adenocarcinoma via THBS2-SDC/Integrin Axes.Int J Mol Sci202642589604PubTator, text miningPubMed
Down-regulation of THBS2 inhibits the malignant progression of Burkitt lymphoma by blocking the PI3K/AKT/c-MYC pathway.Front Oncol202642568393PubTator, text miningPubMed
Proteomic Mediators of Chronic Obstructive Pulmonary Disease Phenotypes and Coronary Artery Calcification Burden in Ever Smokers.J Am Heart Assoc202642568067PubTator, text miningPubMed

1 to 10 of 3,211

See all 3,211 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7058

GET https://conductscience.org/api/genes/v1/7058/patents?page=2