Gene · 7074
TIAM1: TIAM Rac1 associated GEF 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TIAM1: TIAM Rac1 associated GEF 1. Genes, record 7074. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7074
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q13009 | Rho guanine nucleotide exchange factor TIAM1 | 1,591 | 10 | Ensembl, GeneID, HGNC |
Source UniProt
Patents21
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 66626 | Q13009 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 2882 | Q13009 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 2882 | Q13009 | Espacenet |
| US 11884978 B2 | 2024-01-30 | 766 | Q13009 | Espacenet |
| JP 2022141755 A | 2022-09-29 | 438 | Q13009 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 87329 | Q13009 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 190300 | Q13009 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 11559 | Q13009 | Espacenet |
| EP 3504344 A1 | 2019-07-03 | 955 | Q13009 | Espacenet |
| US 10258676 B2 | 2019-04-16 | 99 | Q13009 | Espacenet |
1 to 10 of 21
See all 21 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,538
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TIAM1 papers | Newest fiscal year |
|---|---|---|---|
| R01NS062829 | Signaling Mechanisms Regulating Rho GTPase-Dependent Synaptic Plasticity Underlying Memory in Health and Disease | 10 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 7 | 2025 |
| P30CA086862 | Cancer Center Support Grant | 6 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 5 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| P30EY016665 | Core Grant for Vision Research | 4 | 2025 |
| P20GM103475 | Advancing Competitive Biomedical Research in Puerto Rico | 3 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 3 | 2025 |
| P30CA013330 | Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,538Source NIH's project files
See all 1,538 nih grantsPapers2,121
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Combination of Blastocyst Complementation and Omics Allows Fast Evaluation of Human Pathogenic Mutations in Mice. | Am J Respir Cell Mol Biol | 2026 | 42814875 | PubTator, text mining | PubMed |
| An integrated multiomics-based risk model for predicting the prognosis and immune microenvironment status in patients with papillary thyroid carcinoma. | Gland Surg | 2026 | 42445075 | PubTator, text mining | PubMed |
| Modulation of Oncogenic KRAS Signaling by Branched Actin-driven Cell Membrane Protrusions. | Res Sq | 2026 | 42282028 | PubTator, text mining | PubMed |
| Elevated Expression of Tiam1 Is Associated with Poor Prognosis and Promotes Tumor Progression in Pancreatic Cancer [Retraction]. | Onco Targets Ther | 2026 | 42199563 | PubTator, text mining | PubMed |
| CADM1 and TIAM1 Expressions in Mycosis Fungoides: Diagnostic Significance and Association With Histopathological Parameters. | J Cutan Pathol | 2026 | 42104607 | PubTator, text mining | PubMed |
| Modulation of Oncogenic KRAS Signaling by Branched Actin-driven Cell Membrane Protrusions. | bioRxiv | 2026 | 42039391 | PubTator, text mining | PubMed |
| Retraction: By downregulating TIAM1 expression, microRNA-329 suppresses gastric cancer invasion and growth. | Oncotarget | 2026 | 42024890 | PubTator, text mining | PubMed |
| Retinal ribbon synapses and the potential functional role of TIAM1: A structural and molecular perspective. | Mol Vis | 2026 | 41982461 | PubTator, text mining | PubMed |
| Architects of the Developing Brain: Cytoskeleton-Organizing Molecules in Neurodevelopmental Disorders. | Cells | 2026 | 41892327 | PubTator, text mining | PubMed |
| Crosstalk between KRAS and miRNAs in pancreatic cancer: Opportunities for its diagnosis, prognosis and therapeutic intervention (Review). | Int J Oncol | 2026 | 41860028 | PubTator, text mining | PubMed |
1 to 10 of 2,121
See all 2,121 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/7074
GET https://conductscience.org/api/genes/v1/7074/patents?page=2