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Gene · 7074

TIAM1: TIAM Rac1 associated GEF 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TIAM1: TIAM Rac1 associated GEF 1. Genes, record 7074. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7074

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Gene

Symbol
TIAM1
HGNC
Name
TIAM Rac1 associated GEF 1
HGNC
NCBI Gene ID
7074
NCBI Gene
HGNC ID
HGNC:11805
HGNC
Ensembl
ENSG00000156299
NCBI Gene
Aliases
NEDLDS, TIAM-1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13009Rho guanine nucleotide exchange factor TIAM11,59110Ensembl, GeneID, HGNC

Source UniProt

Patents21

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1466626Q13009Espacenet
EP 4641201 A22025-10-292882Q13009Espacenet
JP 2025517969 A2025-06-122882Q13009Espacenet
US 11884978 B22024-01-30766Q13009Espacenet
JP 2022141755 A2022-09-29438Q13009Espacenet
US 11446398 B22022-09-2087329Q13009Espacenet
JP 2022524081 A2022-04-27190300Q13009Espacenet
US 11078247 B22021-08-0311559Q13009Espacenet
EP 3504344 A12019-07-03955Q13009Espacenet
US 10258676 B22019-04-1699Q13009Espacenet

1 to 10 of 21

See all 21 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,538

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTIAM1 papersNewest fiscal year
R01NS062829Signaling Mechanisms Regulating Rho GTPase-Dependent Synaptic Plasticity Underlying Memory in Health and Disease102025
P30CA016086Cancer Center Support Grant72025
P30CA086862Cancer Center Support Grant62025
P30DK020572Michigan Diabetes Research Center (MDRC)52025
P30CA008748Cancer Center Support Grant42025
P30CA016672Cancer Center Support Grant42025
P30EY016665Core Grant for Vision Research42025
P20GM103475Advancing Competitive Biomedical Research in Puerto Rico32025
P30CA006927Comprehensive Cancer Center Program at Fox Chase32025
P30CA013330Cancer Center Support Grant32025

1 to 10 of 1,538Source NIH's project files

See all 1,538 nih grants

Papers2,121

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Combination of Blastocyst Complementation and Omics Allows Fast Evaluation of Human Pathogenic Mutations in Mice.Am J Respir Cell Mol Biol202642814875PubTator, text miningPubMed
An integrated multiomics-based risk model for predicting the prognosis and immune microenvironment status in patients with papillary thyroid carcinoma.Gland Surg202642445075PubTator, text miningPubMed
Modulation of Oncogenic KRAS Signaling by Branched Actin-driven Cell Membrane Protrusions.Res Sq202642282028PubTator, text miningPubMed
Elevated Expression of Tiam1 Is Associated with Poor Prognosis and Promotes Tumor Progression in Pancreatic Cancer [Retraction].Onco Targets Ther202642199563PubTator, text miningPubMed
CADM1 and TIAM1 Expressions in Mycosis Fungoides: Diagnostic Significance and Association With Histopathological Parameters.J Cutan Pathol202642104607PubTator, text miningPubMed
Modulation of Oncogenic KRAS Signaling by Branched Actin-driven Cell Membrane Protrusions.bioRxiv202642039391PubTator, text miningPubMed
Retraction: By downregulating TIAM1 expression, microRNA-329 suppresses gastric cancer invasion and growth.Oncotarget202642024890PubTator, text miningPubMed
Retinal ribbon synapses and the potential functional role of TIAM1: A structural and molecular perspective.Mol Vis202641982461PubTator, text miningPubMed
Architects of the Developing Brain: Cytoskeleton-Organizing Molecules in Neurodevelopmental Disorders.Cells202641892327PubTator, text miningPubMed
Crosstalk between KRAS and miRNAs in pancreatic cancer: Opportunities for its diagnosis, prognosis and therapeutic intervention (Review).Int J Oncol202641860028PubTator, text miningPubMed

1 to 10 of 2,121

See all 2,121 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7074

GET https://conductscience.org/api/genes/v1/7074/patents?page=2