Gene · 7075
TIE1: tyrosine kinase with immunoglobulin like and EGF like domains 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TIE1: tyrosine kinase with immunoglobulin like and EGF like domains 1. Genes, record 7075. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7075
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P35590 | Tyrosine-protein kinase receptor Tie-1 | 1,138 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents76
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 9109 | P35590 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 9387 | P35590 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 13227 | P35590 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 4668 | P35590 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 7884 | P35590 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 4668 | P35590 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 7884 | P35590 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 9387 | P35590 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 9109 | P35590 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 13227 | P35590 | Espacenet |
1 to 10 of 76
See all 76 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| CP-459632 | CHEMBL3545300 | Tyrosine-protein kinase receptor Tie-1 inhibitor | INHIBITOR |
Source ChEMBL
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,372
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TIE1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 7 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 6 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 4 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 4 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 3 | 2025 |
| P30CA013696 | Cancer Center Support Grant | 3 | 2025 |
| R01EY028996 | Integrin-binding Peptide for Ocular Neovascularization and Macular Edema: Molecular Mechanism of Action | 3 | 2025 |
| P30CA044579 | University of Virginia Cancer Center Support Grant | 2 | 2025 |
| P30CA046934 | University of Colorado Cancer Center Support Grant | 2 | 2025 |
| P30CA072720 | Cancer Center Support Grant | 2 | 2025 |
1 to 10 of 1,372Source NIH's project files
See all 1,372 nih grantsPapers2,045
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Tie1 ectodomain cleavage governs vascular responses to inflammatory stimulation but is dispensable for angiogenic signaling. | J Clin Invest | 2026 | 42820306 | PubTator, text mining | PubMed |
| Targeting Angiogenesis in Drug Discovery: Current Status and Future Directions. | Curr Drug Targets | 2026 | 42725601 | PubTator, text mining | PubMed |
| Proteomics identify disease-associated variants in patients with rare diseases undiagnosed after genome sequencing. | Sci Transl Med | 2026 | 42715344 | PubTator, text mining | PubMed |
| Evaluation of the UK Myeloma Research Alliance risk profile in transplant-ineligible multiple myeloma patients treated with novel agents. | Br J Haematol | 2026 | 42692463 | PubTator, text mining | PubMed |
| Altered ANG/TIE gene expression in advanced ovarian cancer is not accompanied by disproportionate body water accumulation relative to perioperative fluid balance. | Sci Rep | 2026 | 42680803 | PubTator, text mining | PubMed |
| FAK regulates leptin-induced angiogenesis and vasculogenic mimicry in breast cancer. | Med Oncol | 2026 | 42667514 | PubTator, text mining | PubMed |
| Angiopoietin-2 Surpasses Soluble Thrombomodulin and Syndecan-1 in Characterizing Septic Shock and Predicting Mortality--A Prospective Observational Study. | J Inflamm Res | 2026 | 42572750 | PubTator, text mining | PubMed |
| TIE1 acts as a maternal brake on fertilization-independent endosperm development by associating with PRC2 to enforce imprinting. | Nat Plants | 2026 | 42521753 | PubTator, text mining | PubMed |
| Kinase Inhibitor Cardiotoxicity Database (KICDB): a causality-oriented multi-omics database for kinase inhibitor-induced cardiotoxicity. | Br J Pharmacol | 2026 | 42464730 | PubTator, text mining | PubMed |
| Neurovascular unit uncoupling in diabetic retinopathy: molecular mechanisms and stage-adapted therapeutic strategies. | Front Endocrinol (Lausanne) | 2026 | 42460327 | PubTator, text mining | PubMed |
1 to 10 of 2,045
See all 2,045 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/7075
GET https://conductscience.org/api/genes/v1/7075/patents?page=2