ConductScience.org, home

Gene · 7075

TIE1: tyrosine kinase with immunoglobulin like and EGF like domains 1

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. TIE1: tyrosine kinase with immunoglobulin like and EGF like domains 1. Genes, record 7075. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7075

On this page

Gene

Symbol
TIE1
HGNC
Name
tyrosine kinase with immunoglobulin like and EGF like domains 1
HGNC
NCBI Gene ID
7075
NCBI Gene
HGNC ID
HGNC:11809
HGNC
Ensembl
ENSG00000066056
NCBI Gene
Aliases
JTK14, LMPHM11, TIE
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P35590Tyrosine-protein kinase receptor Tie-11,1381Ensembl, GeneID, HGNC

Source UniProt

Patents76

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-199109P35590Espacenet
EP 4641201 A22025-10-299387P35590Espacenet
JP 2025147176 A2025-10-0613227P35590Espacenet
JP 2025529142 A2025-09-044668P35590Espacenet
JP 2025529142 A2025-09-047884P35590Espacenet
US 12371689 B22025-07-294668P35590Espacenet
US 12371689 B22025-07-297884P35590Espacenet
JP 2025517969 A2025-06-129387P35590Espacenet
JP 2025517970 A2025-06-129109P35590Espacenet
JP 2025028160 A2025-02-2813227P35590Espacenet

1 to 10 of 76

See all 76 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
CP-459632CHEMBL3545300Tyrosine-protein kinase receptor Tie-1 inhibitorINHIBITOR

Source ChEMBL

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,372

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTIE1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant72025
P30CA008748Cancer Center Support Grant62025
P30CA016056Roswell Park Cancer Center Support Grant42025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center42025
P30CA006973Regional Oncology Research Center32025
P30CA013696Cancer Center Support Grant32025
R01EY028996Integrin-binding Peptide for Ocular Neovascularization and Macular Edema: Molecular Mechanism of Action32025
P30CA044579University of Virginia Cancer Center Support Grant22025
P30CA046934University of Colorado Cancer Center Support Grant22025
P30CA072720Cancer Center Support Grant22025

1 to 10 of 1,372Source NIH's project files

See all 1,372 nih grants

Papers2,045

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Tie1 ectodomain cleavage governs vascular responses to inflammatory stimulation but is dispensable for angiogenic signaling.J Clin Invest202642820306PubTator, text miningPubMed
Targeting Angiogenesis in Drug Discovery: Current Status and Future Directions.Curr Drug Targets202642725601PubTator, text miningPubMed
Proteomics identify disease-associated variants in patients with rare diseases undiagnosed after genome sequencing.Sci Transl Med202642715344PubTator, text miningPubMed
Evaluation of the UK Myeloma Research Alliance risk profile in transplant-ineligible multiple myeloma patients treated with novel agents.Br J Haematol202642692463PubTator, text miningPubMed
Altered ANG/TIE gene expression in advanced ovarian cancer is not accompanied by disproportionate body water accumulation relative to perioperative fluid balance.Sci Rep202642680803PubTator, text miningPubMed
FAK regulates leptin-induced angiogenesis and vasculogenic mimicry in breast cancer.Med Oncol202642667514PubTator, text miningPubMed
Angiopoietin-2 Surpasses Soluble Thrombomodulin and Syndecan-1 in Characterizing Septic Shock and Predicting Mortality--A Prospective Observational Study.J Inflamm Res202642572750PubTator, text miningPubMed
TIE1 acts as a maternal brake on fertilization-independent endosperm development by associating with PRC2 to enforce imprinting.Nat Plants202642521753PubTator, text miningPubMed
Kinase Inhibitor Cardiotoxicity Database (KICDB): a causality-oriented multi-omics database for kinase inhibitor-induced cardiotoxicity.Br J Pharmacol202642464730PubTator, text miningPubMed
Neurovascular unit uncoupling in diabetic retinopathy: molecular mechanisms and stage-adapted therapeutic strategies.Front Endocrinol (Lausanne)202642460327PubTator, text miningPubMed

1 to 10 of 2,045

See all 2,045 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7075

GET https://conductscience.org/api/genes/v1/7075/patents?page=2