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TIMP2: TIMP metallopeptidase inhibitor 2

1 protein, 165 patents, 0 drugs, 0 trials, 3,864 NIH grants and 11,435 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTIMP2HGNC
NameTIMP metallopeptidase inhibitor 2HGNC
NCBI Gene ID7077NCBI Gene
HGNC IDHGNC:11821HGNC
EnsemblENSG00000035862NCBI Gene
AliasesCSC-21K, DDC8NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P16035Metalloproteinase inhibitor 22204Ensembl, GeneID, HGNCUniProt

Patents 165

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12624121 B22026-05-1245P16035Espacenet
JP 2026513515 A2026-04-287P16035Espacenet
US 12539325 B22026-02-0315P16035Espacenet
EP 4680970 A12026-01-217P16035Espacenet
EP 4650780 A22025-11-192114P16035Espacenet
EP 4641203 A22025-10-2965P16035Espacenet
JP 2025147176 A2025-10-0613246P16035Espacenet
JP 2025529142 A2025-09-047887P16035Espacenet
US 12371689 B22025-07-297887P16035Espacenet
JP 2025099926 A2025-07-037P16035Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 3864

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant182,025NIH's project files
P30EY010572Ophthalmology Core Facility122,025NIH's project files
P50CA116201Mayo Clinic Breast Cancer SPORE92,025NIH's project files
R01CA258274Engineering tissue inhibitor of metalloproteinases-2 (TIMP-2) for triple negative breast cancer therapy92,025NIH's project files
R01GM110240Explainable, Fair, Reproducible and Collaborative Surgical Artificial Intelligence: Integrating data, algorithms and clinical reasoning for surgical risk assessment (XAI-IDEALIST)82,025NIH's project files
P30CA008748Cancer Center Support Grant72,025NIH's project files
P30CA047904Cancer Center Support Grant72,025NIH's project files
P30CA068485Cancer Center Support Grant72,025NIH's project files
P30CA022453CANCER CENTER SUPPORT GRANT62,025NIH's project files
R01EY024698Gene Editing and Silencing in Phototransduction62,025NIH's project files

Papers 11435

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42802967PubTator, text miningPubMed
42798740PubTator, text miningPubMed
42787640PubTator, text miningPubMed
42785046PubTator, text miningPubMed
42783394PubTator, text miningPubMed
42781773PubTator, text miningPubMed
42756889PubTator, text miningPubMed
42751804PubTator, text miningPubMed
42734065PubTator, text miningPubMed
42730910PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license