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NKX2-1: NK2 homeobox 1

1 protein, 69 patents, 0 drugs, 0 trials, 3,374 NIH grants and 9,399 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolNKX2-1HGNC
NameNK2 homeobox 1HGNC
NCBI Gene ID7080NCBI Gene
HGNC IDHGNC:11825HGNC
EnsemblENSG00000136352NCBI Gene
AliasesBCH, BHC, NK-2, NKX2.1, NKX2A, NMTC1, T/EBP, TEBP, TITF1, TTF-1, TTF1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P43699Homeobox protein Nkx-2.13712Ensembl, GeneID, HGNCUniProt

Patents 69

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026027383 A2026-02-1824P43699Espacenet
JP 2025147176 A2025-10-0615392P43699Espacenet
JP 2025147176 A2025-10-0615811P43699Espacenet
JP 2025028160 A2025-02-2815392P43699Espacenet
JP 2025028160 A2025-02-2815811P43699Espacenet
KR 1020250010750 A2025-01-2115392P43699Espacenet
KR 1020250010750 A2025-01-2115811P43699Espacenet
JP 2024123008 A2024-09-107351P43699Espacenet
JP 2024123008 A2024-09-107352P43699Espacenet
JP 2024123008 A2024-09-107353P43699Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 3374

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant822,025NIH's project files
P30CA016672Cancer Center Support Grant542,025NIH's project files
R01HL095993Derivation of lung epithelia from iPS cells for advanced disease modeling242,025NIH's project files
ZIABC005522Thyroid regeneration and carcinogenesis192,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award152,025NIH's project files
P30CA006973Regional Oncology Research Center132,025NIH's project files
P30ES013508Center of Excellence in Environmental Toxicology132,025NIH's project files
P30CA016058Cancer Center Support Grant112,025NIH's project files
P30CA124435Stanford Cancer Institute112,025NIH's project files
P30DK065988UNC Cystic Fibrosis Research and Translation Core Center102,025NIH's project files

Papers 9399

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42801240PubTator, text miningPubMed
42798159PubTator, text miningPubMed
42797068PubTator, text miningPubMed
42793238PubTator, text miningPubMed
42787081PubTator, text miningPubMed
42784847PubTator, text miningPubMed
42784242PubTator, text miningPubMed
42782345PubTator, text miningPubMed
42777370PubTator, text miningPubMed
42771994PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license