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TJP1: tight junction protein 1

1 protein, 25 patents, 0 drugs, 0 trials, 8,001 NIH grants and 20,131 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTJP1HGNC
Nametight junction protein 1HGNC
NCBI Gene ID7082NCBI Gene
HGNC IDHGNC:11827HGNC
EnsemblENSG00000104067NCBI Gene
AliasesDKFZp686M05161, MGC133289, ZO-1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q07157Tight junction protein 11,74819Ensembl, GeneID, HGNCUniProt

Patents 25

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1467134Q07157Espacenet
EP 4650780 A22025-11-193129Q07157Espacenet
EP 4641201 A22025-10-292685Q07157Espacenet
WO 2025177214 A12025-08-2824Q07157Espacenet
JP 2025517969 A2025-06-122685Q07157Espacenet
JP 2025517970 A2025-06-123129Q07157Espacenet
JP 2024522861 A2024-06-2145Q07157Espacenet
JP 2024519218 A2024-05-09161Q07157Espacenet
KR 1020240005837 A2024-01-12161Q07157Espacenet
US 11795436 B22023-10-2417Q07157Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 8001

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01DK061931Mechanisms and pathophysiologic impact of claudin-2 modulation502,025NIH's project files
R01DK068271Therapeutic targeting of protein interactions to reverse MLCK1-mediated intestinal barrier loss and ameliorate disease.472,025NIH's project files
P30DK058404Molecular and Cellular Basis for Digestive Diseases312,025NIH's project files
P30CA008748Cancer Center Support Grant282,025NIH's project files
R01MH072567HIV-1 and amyloid beta interactions at the blood-brain barrier252,025NIH's project files
P30CA016672Cancer Center Support Grant242,025NIH's project files
P30DK034989Yale Liver Center232,025NIH's project files
P30DK034854Integrated Epithelial and Muscosal Biology212,025NIH's project files
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital202,025NIH's project files
P30CA068485Cancer Center Support Grant182,025NIH's project files

Papers 20131

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42819782PubTator, text miningPubMed
42813644PubTator, text miningPubMed
42811980PubTator, text miningPubMed
42805066PubTator, text miningPubMed
42804124PubTator, text miningPubMed
42800590PubTator, text miningPubMed
42799927PubTator, text miningPubMed
42798645PubTator, text miningPubMed
42797076PubTator, text miningPubMed
42794733PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license