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Gene · 7083

TK1: thymidine kinase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TK1: thymidine kinase 1. Genes, record 7083. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7083

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Gene

Symbol
TK1
HGNC
Name
thymidine kinase 1
HGNC
NCBI Gene ID
7083
NCBI Gene
HGNC ID
HGNC:11830
HGNC
Ensembl
ENSG00000167900
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P04183Thymidine kinase, cytosolic2344Ensembl, GeneID, HGNC

Source UniProt

Patents34

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4805733 A12026-09-1628P04183Espacenet
JP 2026004568 A2026-01-1467027P04183Espacenet
JP 2026004568 A2026-01-1467028P04183Espacenet
EP 4650780 A22025-11-194089P04183Espacenet
EP 4641202 A22025-10-294774P04183Espacenet
JP 2025517970 A2025-06-124089P04183Espacenet
KR 1020250017231 A2025-02-044774P04183Espacenet
JP 2024523546 A2024-06-2828P04183Espacenet
US 11959919 B22024-04-163P04183Espacenet
US 11446398 B22022-09-2088654P04183Espacenet

1 to 10 of 34

See all 34 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,173

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTK1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant162025
P30CA016672Cancer Center Support Grant142025
P30CA016058Cancer Center Support Grant112025
P30CA016520Abramson Cancer Center Support Grant72025
P30CA047904Cancer Center Support Grant72025
P30CA091842Cancer Center Support Grant62025
P30CA006973Regional Oncology Research Center52025
P30CA016042Cancer Center Support Grant52025
P30CA068485Cancer Center Support Grant52025
P30CA086862Cancer Center Support Grant52025

1 to 10 of 1,173Source NIH's project files

See all 1,173 nih grants

Papers2,547

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Prognostic role of thymidine kinase 1 activity in hormone receptor positive metastatic breast cancer. A systematic review and meta-analysis.Breast202642727162PubTator, text miningPubMed
Association between thymidine kinase 1 and clinicopathological high-risk features in breast cancer.Medicine (Baltimore)202642675724PubTator, text miningPubMed
Transcriptomic and Metabolomic Profiling Identifies a Core Gene-Metabolite Axis Driving African Swine Fever Virus Replication in the Soft Tick Ornithodoros lahorensis.FASEB J202642671168PubTator, text miningPubMed
A human stem cell model of neuroblastoma identifies four chromosome 17q genes that drive tumor initiation and progression.Cancer Lett202642648464PubTator, text miningPubMed
Th17 Cell-Related Gene Biomarkers in Autoimmune Thyroiditis: Comprehensive Bioinformatics Analysis and In Vivo Validation.Comb Chem High Throughput Screen202642634370PubTator, text miningPubMed
Targeting a CDH1-TK1-dependent DNA Synthesis Pathway Overcomes Chemoresistance in Acute Myeloid Leukemia.Hematol Oncol202642570285PubTator, text miningPubMed
Palmitoylation of TK1 exacerbates osteoarthritis by promoting JNK-mediated metabolic reprogramming.Proc Natl Acad Sci U S A202642546205PubTator, text miningPubMed
Integrating network toxicology and in vitro validation to elucidate PET microplastic-induced osteoarthritis pathogenesis.Front Pharmacol202642453583PubTator, text miningPubMed
Peripheral Blood DNA Methylation Changes Precede Lymphoma Diagnosis in Primary Sjögren's Disease.Arthritis Rheumatol202642421555PubTator, text miningPubMed
Utilizing Single-Cell and Transcriptomic Data to Identify Mitochondrial Pathway-Associated Prognostic Genes and Their Regulatory Mechanisms of Action in Ovarian Cancer.FASEB J202642387880PubTator, text miningPubMed

1 to 10 of 2,547

See all 2,547 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7083

GET https://conductscience.org/api/genes/v1/7083/patents?page=2