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Gene · 7086

TKT: transketolase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TKT: transketolase. Genes, record 7086. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7086

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Gene

Symbol
TKT
HGNC
Name
transketolase
HGNC
NCBI Gene ID
7086
NCBI Gene
HGNC ID
HGNC:11834
HGNC
Ensembl
ENSG00000163931
NCBI Gene
Aliases
HEL-S-48, HEL107, SDDHD, TK, TKT1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P29401Transketolase62313Ensembl, GeneID, HGNC

Source UniProt

Patents58

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026063308 A2026-03-2628P29401Espacenet
JP 2026004568 A2026-01-1467679P29401Espacenet
JP 2026004568 A2026-01-1467680P29401Espacenet
EP 4650780 A22025-11-1913343P29401Espacenet
EP 4641201 A22025-10-2915179P29401Espacenet
EP 4641202 A22025-10-296617P29401Espacenet
JP 2025517969 A2025-06-1215179P29401Espacenet
JP 2025517970 A2025-06-1213343P29401Espacenet
KR 1020250017231 A2025-02-046617P29401Espacenet
WO 2024240908 A12024-11-2813P29401Espacenet

1 to 10 of 58

See all 58 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,450

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTKT papersNewest fiscal year
P30CA008748Cancer Center Support Grant92025
P30CA016672Cancer Center Support Grant92025
P30CA177558University of Kentucky Markey Cancer Center – Cancer Center Support Grant92025
P20GM121327University of Kentucky Center for Cancer Metabolism62025
P30ES013508Center of Excellence in Environmental Toxicology42025
R01AA005965CNS Deficits: Interaction of Age and Alcoholism42025
P30CA010815Consolidated Basic Cancer Research Program32025
P30CA091842Cancer Center Support Grant32025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control32025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal32025

1 to 10 of 1,450Source NIH's project files

See all 1,450 nih grants

Papers3,154

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A general method for the assay of thiamine pyrophosphokinase activity.Methods Enzymol202642778273PubTator, text miningPubMed
Protocol for the measurement of human brain transketolase activity.Methods Enzymol202642778272PubTator, text miningPubMed
Assessment of thiamine status in humans.Methods Enzymol202642778271PubTator, text miningPubMed
Transketolase promotes RNF20-dependent H2BK120 ubiquitination and DNA repair through a non-enzymatic adaptor function.FEBS J202642713978PubTator, text miningPubMed
Exploring Inhibitory Impacts of Anamorelin on Colorectal Cancer Proliferation via Regulation of Transketolase.Curr Med Chem202642693844PubTator, text miningPubMed
Thiamine diphosphate-dependent enzymes: mechanistic principles, stereoselective C-C bond formation, and synthetic biocatalytic applications.Org Biomol Chem202642638609PubTator, text miningPubMed
Chronic Stress-Induced m7G Cap Modification of ADRB2 Dysregulates the Pentose Phosphate Pathway to Promote Esophageal Squamous Cell Carcinoma Progression.Cancer Res202642555660PubTator, text miningPubMed
TKTL1 mediates metabolic adaptation and stress resistance in pancreatic cancer cells under nutrient-deprived conditions.Oncogene202642533116PubTator, text miningPubMed
Systematic review of extracellular vesicle-based liquid biopsy for leptomeningeal metastasis: current evidence and future directions.Clin Exp Metastasis202642484930PubTator, text miningPubMed
Targeting TKT-associated immunometabolic remodeling attenuates experimental lupus nephritis and NET-related inflammation.Front Cell Dev Biol202642459832PubTator, text miningPubMed

1 to 10 of 3,154

See all 3,154 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7086

GET https://conductscience.org/api/genes/v1/7086/patents?page=2