Gene · 7088
TLE1: TLE family member 1, transcriptional corepressor
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TLE1: TLE family member 1, transcriptional corepressor. Genes, record 7088. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7088
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q04724 | Transducin-like enhancer protein 1 | 770 | 6 | Ensembl, GeneID, HGNC |
Source UniProt
Patents28
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 67469 | Q04724 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 9785 | Q04724 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 10039 | Q04724 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 10039 | Q04724 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 9785 | Q04724 | Espacenet |
| US 11987605 B2 | 2024-05-21 | 23 | Q04724 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 90001 | Q04724 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 192972 | Q04724 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 247904 | Q04724 | Espacenet |
| JP 2017132796 A | 2017-08-03 | 278 | Q04724 | Espacenet |
1 to 10 of 28
See all 28 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants875
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TLE1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 29 | 2025 |
| P50CA217694 | SPORE in Soft Tissue Sarcoma | 14 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 6 | 2025 |
| P30CA042014 | Cancer Center Support Grant | 5 | 2025 |
| P30CA030199 | Cancer Center Support Grant (CCSG) | 4 | 2025 |
| P30CA014236 | Cancer Center Support Grant (CCSG) | 3 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| P30CA086862 | Cancer Center Support Grant | 3 | 2025 |
| K12CA076931 | Physician Scientist Training in Clinical Oncology | 2 | 2025 |
| P01AI063302 | The intersection of innate and adaptive immunity to intracellular pathogens | 2 | 2025 |
1 to 10 of 875Source NIH's project files
See all 875 nih grantsPapers1,414
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| MGA::NUTM1 fusion sarcoma: expanding the spectrum of NUT-rearranged sarcomas with extensive review of the literature. | Am J Clin Pathol | 2026 | 42771852 | PubTator, text mining | PubMed |
| Virologic outcomes among people living with HIV on dolutegravir-based antiretroviral therapy in Kenya, 2018-2024: a comparison retrospective longitudinal analysis. | Lancet Reg Health Afr | 2026 | 42761759 | PubTator, text mining | PubMed |
| Primary ovarian synovial sarcoma in an adolescent mimicking a germ cell tumor: A case report and diagnostic challenge. | Gynecol Oncol Rep | 2026 | 42555456 | PubTator, text mining | PubMed |
| Host transcriptional corepressor TLE1 is commonly exploited by RNA viruses for replication. | Mol Cell | 2026 | 42480521 | PubTator, text mining | PubMed |
| RETRACTION: Lnc-GIHCG Promotes Cell Proliferation and Migration in Gastric Cancer through miR- 1281 Adsorption. | Mol Genet Genomic Med | 2026 | 42452948 | PubTator, text mining | PubMed |
| Primary renal synovial sarcoma: a clinicopathological study of 23 cases highlighting the diagnostic value of SS18-SSX, TLE1, and INI1 immunohistochemistry panel. | Virchows Arch | 2026 | 42371005 | PubTator, text mining | PubMed |
| Systemic degradation of repressive transcription factors gates gene expression and cell fate specification. | bioRxiv | 2026 | 42367945 | PubTator, text mining | PubMed |
| SMARCB1-Deficient Malignant Orbital Neoplasm with Features Overlapping Myxoid Epithelioid Sarcoma: A Diagnostic Challenge. | Head Neck Pathol | 2026 | 42340513 | PubTator, text mining | PubMed |
| Diagnostic challenges in synovial sarcoma: a case report. | J Med Case Rep | 2026 | 42324560 | PubTator, text mining | PubMed |
Critical Biological Functions and Clinical Implications of Epigenetic-Related Candidate Biomarkers in Chronic Obstructive Pulmonary Disease: Integrated Machine Learning Screening and Basic Experimental Validation. | Int J Chron Obstruct Pulmon Dis | 2026 | 42292533 | PubTator, text mining | PubMed |
1 to 10 of 1,414
See all 1,414 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/7088
GET https://conductscience.org/api/genes/v1/7088/patents?page=2