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Gene · 7088

TLE1: TLE family member 1, transcriptional corepressor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TLE1: TLE family member 1, transcriptional corepressor. Genes, record 7088. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7088

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Gene

Symbol
TLE1
HGNC
Name
TLE family member 1, transcriptional corepressor
HGNC
NCBI Gene ID
7088
NCBI Gene
HGNC ID
HGNC:11837
HGNC
Ensembl
ENSG00000196781
NCBI Gene
Aliases
ESG, ESG1, GRG1, TLE-1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q04724Transducin-like enhancer protein 17706Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1467469Q04724Espacenet
EP 4650780 A22025-11-199785Q04724Espacenet
EP 4641201 A22025-10-2910039Q04724Espacenet
JP 2025517969 A2025-06-1210039Q04724Espacenet
JP 2025517970 A2025-06-129785Q04724Espacenet
US 11987605 B22024-05-2123Q04724Espacenet
US 11446398 B22022-09-2090001Q04724Espacenet
JP 2022524081 A2022-04-27192972Q04724Espacenet
JP 2019054813 A2019-04-11247904Q04724Espacenet
JP 2017132796 A2017-08-03278Q04724Espacenet

1 to 10 of 28

See all 28 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants875

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTLE1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant292025
P50CA217694SPORE in Soft Tissue Sarcoma142025
P30CA021765Cancer Center Support Grant (CCSG)62025
P30CA042014Cancer Center Support Grant52025
P30CA030199Cancer Center Support Grant (CCSG)42025
P30CA014236Cancer Center Support Grant (CCSG)32025
P30CA016672Cancer Center Support Grant32025
P30CA086862Cancer Center Support Grant32025
K12CA076931Physician Scientist Training in Clinical Oncology22025
P01AI063302The intersection of innate and adaptive immunity to intracellular pathogens22025

1 to 10 of 875Source NIH's project files

See all 875 nih grants

Papers1,414

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
MGA::NUTM1 fusion sarcoma: expanding the spectrum of NUT-rearranged sarcomas with extensive review of the literature.Am J Clin Pathol202642771852PubTator, text miningPubMed
Virologic outcomes among people living with HIV on dolutegravir-based antiretroviral therapy in Kenya, 2018-2024: a comparison retrospective longitudinal analysis.Lancet Reg Health Afr202642761759PubTator, text miningPubMed
Primary ovarian synovial sarcoma in an adolescent mimicking a germ cell tumor: A case report and diagnostic challenge.Gynecol Oncol Rep202642555456PubTator, text miningPubMed
Host transcriptional corepressor TLE1 is commonly exploited by RNA viruses for replication.Mol Cell202642480521PubTator, text miningPubMed
RETRACTION: Lnc-GIHCG Promotes Cell Proliferation and Migration in Gastric Cancer through miR- 1281 Adsorption.Mol Genet Genomic Med202642452948PubTator, text miningPubMed
Primary renal synovial sarcoma: a clinicopathological study of 23 cases highlighting the diagnostic value of SS18-SSX, TLE1, and INI1 immunohistochemistry panel.Virchows Arch202642371005PubTator, text miningPubMed
Systemic degradation of repressive transcription factors gates gene expression and cell fate specification.bioRxiv202642367945PubTator, text miningPubMed
SMARCB1-Deficient Malignant Orbital Neoplasm with Features Overlapping Myxoid Epithelioid Sarcoma: A Diagnostic Challenge.Head Neck Pathol202642340513PubTator, text miningPubMed
Diagnostic challenges in synovial sarcoma: a case report.J Med Case Rep202642324560PubTator, text miningPubMed
Critical Biological Functions and Clinical Implications of Epigenetic-Related Candidate Biomarkers in Chronic Obstructive Pulmonary Disease: Integrated Machine Learning Screening and Basic Experimental Validation.
Int J Chron Obstruct Pulmon Dis202642292533PubTator, text miningPubMed

1 to 10 of 1,414

See all 1,414 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7088

GET https://conductscience.org/api/genes/v1/7088/patents?page=2