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TLR2: toll like receptor 2

1 protein, 123 patents, 2 drugs, 7 trials, 13,710 NIH grants and 35,324 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTLR2HGNC
Nametoll like receptor 2HGNC
NCBI Gene ID7097NCBI Gene
HGNC IDHGNC:11848HGNC
EnsemblENSG00000137462NCBI Gene
AliasesCD282, TIL4NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O60603Toll-like receptor 27847Ensembl, GeneID, HGNCUniProt

Patents 123

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1467223O60603Espacenet
EP 4650780 A22025-11-191775O60603Espacenet
EP 4641201 A22025-10-291363O60603Espacenet
EP 4641202 A22025-10-2984O60603Espacenet
EP 4641203 A22025-10-2955O60603Espacenet
JP 2025529142 A2025-09-044680O60603Espacenet
US 12371689 B22025-07-294680O60603Espacenet
US 12365711 B22025-07-2217O60603Espacenet
JP 2025517967 A2025-06-1255O60603Espacenet
JP 2025517969 A2025-06-121363O60603Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
TOMARALIMABCHEMBL4298067Toll-like receptor 2 antagonistANTAGONISTChEMBL
VB-201CHEMBL4297333Toll-like receptor 2 inhibitorINHIBITORChEMBL

Trials 7

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04939311VB-201PHASE1/PHASE2ClinicalTrials.gov
NCT04733833VB-201PHASE2ClinicalTrials.gov
NCT03337451TOMARALIMABPHASE1/PHASE2ClinicalTrials.gov
NCT02363491TOMARALIMABPHASE1/PHASE2ClinicalTrials.gov
NCT01839214VB-201PHASE2ClinicalTrials.gov
NCT01837420VB-201PHASE2ClinicalTrials.gov
NCT01001468VB-201PHASE2ClinicalTrials.gov

NIH grants 13710

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital582,025NIH's project files
P30CA016672Cancer Center Support Grant452,025NIH's project files
P51OD011104Tulane National Primate Research Center392,025NIH's project files
P51OD011132Emory National Primate Research Center372,025NIH's project files
P30CA008748Cancer Center Support Grant342,025NIH's project files
P51OD011092Support for National Primate Research Center312,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award312,025NIH's project files
P30EY011373CWRU NEI Vision Center Core Grant302,025NIH's project files
P30AI036219Rustbelt Center for AIDS Research (Case/UHC-Pitt CFAR)272,025NIH's project files
R01AI022553Molecular Analysis of Host Immune Response in Leprosy262,025NIH's project files

Papers 35324

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824924PubTator, text miningPubMed
42821824PubTator, text miningPubMed
42818209PubTator, text miningPubMed
42816669PubTator, text miningPubMed
42813828PubTator, text miningPubMed
42812399PubTator, text miningPubMed
42812170PubTator, text miningPubMed
42805970PubTator, text miningPubMed
42804734PubTator, text miningPubMed
42800364PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license