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TLR3: toll like receptor 3

1 protein, 175 patents, 3 drugs, 29 trials, 9,613 NIH grants and 20,912 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTLR3HGNC
Nametoll like receptor 3HGNC
NCBI Gene ID7098NCBI Gene
HGNC IDHGNC:11849HGNC
EnsemblENSG00000164342NCBI Gene
AliasesCD283, IIAE2, IMD83NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O15455Toll-like receptor 390420Ensembl, GeneID, HGNCUniProt

Patents 175

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026515744 A2026-05-19108O15455Espacenet
JP 2026004568 A2026-01-1467224O15455Espacenet
JP 2025538131 A2025-11-2692O15455Espacenet
EP 4650780 A22025-11-193772O15455Espacenet
EP 4640849 A22025-10-29488O15455Espacenet
EP 4641201 A22025-10-293346O15455Espacenet
EP 4641202 A22025-10-29196O15455Espacenet
EP 4641203 A22025-10-29126O15455Espacenet
JP 2025147176 A2025-10-0613270O15455Espacenet
EP 4611777 A12025-09-1092O15455Espacenet

Drugs 3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BEVASIRANIBCHEMBL2110581Toll-like receptor 3 activatorACTIVATORChEMBL
BEVASIRANIB SODIUMCHEMBL2103797Toll-like receptor 3 activatorACTIVATORChEMBL
RINTATOLIMODCHEMBL2107862Toll-like receptor 3 agonistAGONISTChEMBL

Trials 29

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05927142RINTATOLIMODPHASE1/PHASE2ClinicalTrials.gov
NCT05756166RINTATOLIMODPHASE1/PHASE2ClinicalTrials.gov
NCT05494697RINTATOLIMODPHASE2ClinicalTrials.gov
NCT04379518RINTATOLIMODPHASE1/PHASE22026-01-13ClinicalTrials.gov
NCT04119830RINTATOLIMODPHASE2ClinicalTrials.gov
NCT04093323RINTATOLIMODPHASE22026-02-25ClinicalTrials.gov
NCT04081389RINTATOLIMODPHASE12023-09-11ClinicalTrials.gov
NCT03899987RINTATOLIMODPHASE2ClinicalTrials.gov
NCT03734692RINTATOLIMODPHASE1/PHASE22025-07-20ClinicalTrials.gov
NCT03599453RINTATOLIMODEARLY_PHASE1ClinicalTrials.gov

NIH grants 9613

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success572,025NIH's project files
P30CA016672Cancer Center Support Grant372,025NIH's project files
P30CA008748Cancer Center Support Grant312,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award262,025NIH's project files
P60AA011605Molecular and Circuit Pathogenesis of Alcohol Use Disorders242,025NIH's project files
R01AI163029Inborn errors of immunity in patients with life-threatening COVID-19212,025NIH's project files
P30DK034854Integrated Epithelial and Muscosal Biology192,025NIH's project files
U19AI089992Immune signatures of vaccine responses in vulnerable populations192,025NIH's project files
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital182,025NIH's project files
U19AI057266Vaccine and Infection Induced Immunity in the Young and Aged182,025NIH's project files

Papers 20912

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824691PubTator, text miningPubMed
42823874PubTator, text miningPubMed
42820461PubTator, text miningPubMed
42812399PubTator, text miningPubMed
42810274PubTator, text miningPubMed
42809926PubTator, text miningPubMed
42805066PubTator, text miningPubMed
42801944PubTator, text miningPubMed
42800308PubTator, text miningPubMed
42792959PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license