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TLR4: toll like receptor 4

1 protein, 173 patents, 3 drugs, 8 trials, 22,734 NIH grants and 77,152 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTLR4HGNC
Nametoll like receptor 4HGNC
NCBI Gene ID7099NCBI Gene
HGNC IDHGNC:11850HGNC
EnsemblENSG00000136869NCBI Gene
AliasesARMD10, CD284, TLR-4, TOLL, hTollNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O00206Toll-like receptor 483915Ensembl, GeneID, HGNCUniProt

Patents 173

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4777520 A12026-07-224O00206Espacenet
JP 2026515744 A2026-05-19166O00206Espacenet
WO 2025259600 A22025-12-1852O00206Espacenet
WO 2025253118 A22025-12-111O00206Espacenet
JP 2025538131 A2025-11-2693O00206Espacenet
EP 4650780 A22025-11-199412O00206Espacenet
EP 4640849 A22025-10-291412O00206Espacenet
EP 4641201 A22025-10-299652O00206Espacenet
EP 4611777 A12025-09-1093O00206Espacenet
JP 2025529142 A2025-09-044682O00206Espacenet

Drugs 3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ERITORANCHEMBL501259Toll-like receptor 4/MD-2 antagonistANTAGONISTChEMBL
ERITORAN TETRASODIUMCHEMBL3301672Toll-like receptor 4/MD-2 antagonistANTAGONISTChEMBL
RESATORVIDCHEMBL225157Toll-like receptor 4 inhibitorINHIBITORChEMBL

Trials 8

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06890039RESATORVIDPHASE2ClinicalTrials.gov
NCT04620148RESATORVIDPHASE2ClinicalTrials.gov
NCT02735707ERITORANPHASE3ClinicalTrials.gov
NCT02267317ERITORANPHASE22020-03-04ClinicalTrials.gov
NCT00633477RESATORVIDPHASE32013-01-09ClinicalTrials.gov
NCT00334828ERITORAN TETRASODIUMPHASE3ClinicalTrials.gov
NCT00143611RESATORVIDPHASE3ClinicalTrials.gov
NCT00046072ERITORAN TETRASODIUMPHASE2ClinicalTrials.gov

NIH grants 22734

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant792,025NIH's project files
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital752,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award702,025NIH's project files
P30CA008748Cancer Center Support Grant612,025NIH's project files
P50AA011999Southern California Research Center for ALPD and Cirrhosis562,025NIH's project files
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)492,025NIH's project files
P30DK034854Integrated Epithelial and Muscosal Biology482,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)452,025NIH's project files
P30DK034989Yale Liver Center412,025NIH's project files
P30DK058404Molecular and Cellular Basis for Digestive Diseases402,025NIH's project files

Papers 77152

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824924PubTator, text miningPubMed
42824893PubTator, text miningPubMed
42824032PubTator, text miningPubMed
42822730PubTator, text miningPubMed
42822010PubTator, text miningPubMed
42821824PubTator, text miningPubMed
42821462PubTator, text miningPubMed
42821369PubTator, text miningPubMed
42821123PubTator, text miningPubMed
42821069PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license