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TLR5: toll like receptor 5

1 protein, 89 patents, 1 drug, 2 trials, 4,021 NIH grants and 7,138 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTLR5HGNC
Nametoll like receptor 5HGNC
NCBI Gene ID7100NCBI Gene
HGNC IDHGNC:11851HGNC
EnsemblENSG00000187554NCBI Gene
AliasesFLJ10052, MELIOS, MGC126430, MGC126431, SLE1, SLEB1, TIL3NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O60602Toll-like receptor 58582Ensembl, GeneID, HGNCUniProt

Patents 89

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1916122O60602Espacenet
EP 4641201 A22025-10-2919613O60602Espacenet
EP 4641202 A22025-10-291096O60602Espacenet
EP 4641203 A22025-10-29626O60602Espacenet
JP 2025517967 A2025-06-12626O60602Espacenet
JP 2025517969 A2025-06-1219613O60602Espacenet
JP 2025517970 A2025-06-1216122O60602Espacenet
US 12274744 B22025-04-15276O60602Espacenet
KR 1020250017230 A2025-02-04626O60602Espacenet
KR 1020250017231 A2025-02-041096O60602Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ENTOLIMODCHEMBL2108683Toll-like receptor 5 agonistAGONISTChEMBL

Trials 2

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02715882ENTOLIMODPHASE2ClinicalTrials.gov
NCT01728480ENTOLIMODPHASE1ClinicalTrials.gov

NIH grants 4021

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
U19AI057266Vaccine and Infection Induced Immunity in the Young and Aged212,025NIH's project files
P30DK034854Integrated Epithelial and Muscosal Biology162,025NIH's project files
P30CA016672Cancer Center Support Grant132,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant122,025NIH's project files
U19AI089992Immune signatures of vaccine responses in vulnerable populations122,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award112,025NIH's project files
P30CA023108Cancer Center Support Grant102,025NIH's project files
P30DK034989Yale Liver Center102,025NIH's project files
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital102,025NIH's project files
P01CA116087H. pylori-induced Inflammation and Gastric Cancer92,025NIH's project files

Papers 7138

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42818209PubTator, text miningPubMed
42780590PubTator, text miningPubMed
42752214PubTator, text miningPubMed
42730814PubTator, text miningPubMed
42697828PubTator, text miningPubMed
42655771PubTator, text miningPubMed
42650137PubTator, text miningPubMed
42650004PubTator, text miningPubMed
42608252PubTator, text miningPubMed
42599928PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license