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TMPRSS2: transmembrane serine protease 2

1 protein, 61 patents, 0 drugs, 0 trials, 5,808 NIH grants and 18,351 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTMPRSS2HGNC
Nametransmembrane serine protease 2HGNC
NCBI Gene ID7113NCBI Gene
HGNC IDHGNC:11876HGNC
EnsemblENSG00000184012NCBI Gene
AliasesPRSS10NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O15393Transmembrane protease serine 249234Ensembl, GeneID, HGNCUniProt

Patents 61

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12605438 B22026-04-211O15393Espacenet
EP 4641201 A22025-10-295571O15393Espacenet
JP 2025529142 A2025-09-044978O15393Espacenet
EP 4602367 A22025-08-2016O15393Espacenet
US 12371689 B22025-07-294978O15393Espacenet
JP 2025517969 A2025-06-125571O15393Espacenet
EP 4509529 A12025-02-194O15393Espacenet
US 12180481 B22024-12-3137O15393Espacenet
WO 2024252183 A12024-12-1224O15393Espacenet
EP 4463572 A12024-11-2016O15393Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 5808

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P50CA097186The Pacific Northwest Prostate Cancer SPORE1142,025NIH's project files
P30CA008748Cancer Center Support Grant1052,025NIH's project files
P30CA006973Regional Oncology Research Center752,025NIH's project files
P50CA092629SPORE in Prostate Cancer612,025NIH's project files
P01CA163227Androgen Receptor Action in Castration Resistant Prostate Cancer522,025NIH's project files
P30CA016672Cancer Center Support Grant522,025NIH's project files
P50CA186786Michigan Prostate SPORE 2025-2030512,025NIH's project files
U01CA113913Prostate Cancer Biomarker and Imaging Validation Alliance: Emory University, University of Alabama Birmingham, and University of Texas Southwestern452,025NIH's project files
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant372,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant322,025NIH's project files

Papers 18351

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825912PubTator, text miningPubMed
42798753PubTator, text miningPubMed
42797768PubTator, text miningPubMed
42793681PubTator, text miningPubMed
42793280PubTator, text miningPubMed
42792860PubTator, text miningPubMed
42763169PubTator, text miningPubMed
42763006PubTator, text miningPubMed
42753605PubTator, text miningPubMed
42747672PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license