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TNF: tumor necrosis factor

1 protein, 743 patents, 15 drugs, 1,262 trials, 74,014 NIH grants and 466,394 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTNFHGNC
Nametumor necrosis factorHGNC
NCBI Gene ID7124NCBI Gene
HGNC IDHGNC:11892HGNC
EnsemblENSG00000232810NCBI Gene
AliasesDIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1FNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P01375Tumor necrosis factor23352Ensembl, GeneID, HGNCUniProt

Patents 743

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026167214 A12026-08-1389P01375Espacenet
EP 4763982 A22026-06-2415P01375Espacenet
US 12653852 B22026-06-1640P01375Espacenet
EP 4754237 A12026-06-1023P01375Espacenet
US 12642832 B22026-06-0215P01375Espacenet
JP 2026510624 A2026-04-1020P01375Espacenet
WO 2026054037 A2026-03-1229P01375Espacenet
WO 2026054039 A2026-03-1228P01375Espacenet
EP 4705273 A22026-03-11325P01375Espacenet
EP 4705483 A12026-03-1114P01375Espacenet

Drugs 15

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABBV-3373CHEMBL4297572TNF-alpha binding agentBINDING AGENTChEMBL
ADALIMUMABCHEMBL1201580TNF-alpha inhibitorINHIBITORChEMBL
AFELIMOMABCHEMBL2108887TNF-alpha inhibitorINHIBITORChEMBL
AZ9773CHEMBL2109587TNF-alpha inhibitorINHIBITORChEMBL
CERTOLIZUMAB PEGOLCHEMBL1201831TNF-alpha inhibitorINHIBITORChEMBL
ETANERCEPTCHEMBL1201572TNF-alpha inhibitorINHIBITORChEMBL
GOLIMUMABCHEMBL1201833TNF-alpha inhibitorINHIBITORChEMBL
INFLIXIMABCHEMBL1201581TNF-alpha inhibitorINHIBITORChEMBL
LENERCEPTCHEMBL2108208TNF-alpha inhibitorINHIBITORChEMBL
NERELIMOMABCHEMBL2108566TNF-alpha inhibitorINHIBITORChEMBL

Trials 1262

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07564505ADALIMUMABPHASE4ClinicalTrials.gov
NCT07550673INFLIXIMABPHASE4ClinicalTrials.gov
NCT07529925ADALIMUMABPHASE4ClinicalTrials.gov
NCT07519005ETANERCEPTEARLY_PHASE1ClinicalTrials.gov
NCT07510191ADALIMUMABPHASE4ClinicalTrials.gov
NCT07510191INFLIXIMABPHASE4ClinicalTrials.gov
NCT07495644ADALIMUMABClinicalTrials.gov
NCT07495644INFLIXIMABClinicalTrials.gov
NCT07495644GOLIMUMABClinicalTrials.gov
NCT07491913ADALIMUMABClinicalTrials.gov

NIH grants 74014

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant8302,025NIH's project files
P30CA008748Cancer Center Support Grant6422,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award3812,025NIH's project files
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital2432,025NIH's project files
P30CA016058Cancer Center Support Grant2302,025NIH's project files
R01AI015614Pathogenesis of Fever in Man2002,025NIH's project files
P30CA047904Cancer Center Support Grant1952,025NIH's project files
P30AI027763UCSF-Bay Area Center for AIDS Research1802,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)1722,025NIH's project files
P30DK058404Molecular and Cellular Basis for Digestive Diseases1722,025NIH's project files

Papers 466394

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827453PubTator, text miningPubMed
42827396PubTator, text miningPubMed
42827322PubTator, text miningPubMed
42826830PubTator, text miningPubMed
42826430PubTator, text miningPubMed
42826090PubTator, text miningPubMed
42825992PubTator, text miningPubMed
42825942PubTator, text miningPubMed
42825916PubTator, text miningPubMed
42825912PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license