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TNNI3: troponin I3, cardiac type

1 protein, 82 patents, 1 drug, 41 trials, 2,812 NIH grants and 11,184 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTNNI3HGNC
Nametroponin I3, cardiac typeHGNC
NCBI Gene ID7137NCBI Gene
HGNC IDHGNC:11947HGNC
EnsemblENSG00000129991NCBI Gene
AliasesCMD1FF, CMD2A, CMH7, RCM1, TNNC1, cTNI, cTnINCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P19429Troponin I, cardiac muscle21039Ensembl, GeneID, HGNCUniProt

Patents 82

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4824266 A12026-10-2156P19429Espacenet
EP 4773979 A12026-07-15176P19429Espacenet
JP 2026513515 A2026-04-281P19429Espacenet
US 12564647 B22026-03-03212P19429Espacenet
EP 4680970 A12026-01-211P19429Espacenet
JP 2026004568 A2026-01-1468356P19429Espacenet
JP 2025166830 A2025-11-0633P19429Espacenet
EP 4630814 A12025-10-153P19429Espacenet
EP 4594752 A12025-08-061P19429Espacenet
JP 2025512333 A2025-04-17792P19429Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
LEVOSIMENDANCHEMBL2051955Troponin, cardiac muscle positive modulatorPOSITIVE MODULATORChEMBL

Trials 41

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07436689LEVOSIMENDANPHASE3ClinicalTrials.gov
NCT07288398LEVOSIMENDANPHASE3ClinicalTrials.gov
NCT07186062LEVOSIMENDANClinicalTrials.gov
NCT06478667LEVOSIMENDANPHASE3ClinicalTrials.gov
NCT06021587LEVOSIMENDANClinicalTrials.gov
NCT05983250LEVOSIMENDANPHASE3ClinicalTrials.gov
NCT05768230LEVOSIMENDANPHASE2/PHASE3ClinicalTrials.gov
NCT05730907LEVOSIMENDANClinicalTrials.gov
NCT04728932LEVOSIMENDANPHASE3ClinicalTrials.gov
NCT04718350LEVOSIMENDANClinicalTrials.gov

NIH grants 2812

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01HL105826Fast myosin binding protein-C and cardiac contractility in heart failure122,025NIH's project files
R01HL075619Integrative Approach to Divergent Remodeling in Thin Filament Cardiomyopathies112,025NIH's project files
R01HL128368Engineered Stem Cells for Cardiac Repair102,025NIH's project files
P30DK017047Diabetes Research Center92,025NIH's project files
R01HL130020Elucidating Mechanism of Cardiac Fibrosis with Cell Village of Pooled Human iPSCs92,025NIH's project files
R01HL132401Mechanisms and Therapeutic Targeting of DNA Damage in Dilated Cardiomyopathy Caused by LMNA Mutations92,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award92,025NIH's project files
P2CHD050924Carolina Population Center82,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)82,025NIH's project files
T32HL094301Noninvasive Cardiovascular Imaging Research Training Program82,025NIH's project files

Papers 11184

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42819979PubTator, text miningPubMed
42812459PubTator, text miningPubMed
42805449PubTator, text miningPubMed
42799895PubTator, text miningPubMed
42796241PubTator, text miningPubMed
42792638PubTator, text miningPubMed
42785497PubTator, text miningPubMed
42784939PubTator, text miningPubMed
42783189PubTator, text miningPubMed
42781365PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license