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TNNT2: troponin T2, cardiac type

1 protein, 11 patents, 1 drug, 41 trials, 3,569 NIH grants and 10,023 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTNNT2HGNC
Nametroponin T2, cardiac typeHGNC
NCBI Gene ID7139NCBI Gene
HGNC IDHGNC:11949HGNC
EnsemblENSG00000118194NCBI Gene
AliasesCMD1D, CMH2, CMPD2, LVNC6, RCM3, TnTC, cTnTNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P45379Troponin T, cardiac muscle29825Ensembl, GeneID, HGNCUniProt

Patents 11

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2025214477 A12025-10-1671P45379Espacenet
WO 2025133043 A12025-06-261P45379Espacenet
WO 2025133083 A12025-06-261P45379Espacenet
WO 2025017153 A12025-01-2324P45379Espacenet
US 11446398 B22022-09-2093064P45379Espacenet
JP 2022524081 A2022-04-27196035P45379Espacenet
WO 2020187790 A12020-09-245P45379Espacenet
EP 3708180 A12020-09-165P45379Espacenet
JP 2016008194 A2016-01-1830P45379Espacenet
JP 2016008195 A2016-01-1830P45379Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
LEVOSIMENDANCHEMBL2051955Troponin, cardiac muscle positive modulatorPOSITIVE MODULATORChEMBL

Trials 41

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07436689LEVOSIMENDANPHASE3ClinicalTrials.gov
NCT07288398LEVOSIMENDANPHASE3ClinicalTrials.gov
NCT07186062LEVOSIMENDANClinicalTrials.gov
NCT06478667LEVOSIMENDANPHASE3ClinicalTrials.gov
NCT06021587LEVOSIMENDANClinicalTrials.gov
NCT05983250LEVOSIMENDANPHASE3ClinicalTrials.gov
NCT05768230LEVOSIMENDANPHASE2/PHASE3ClinicalTrials.gov
NCT05730907LEVOSIMENDANClinicalTrials.gov
NCT04728932LEVOSIMENDANPHASE3ClinicalTrials.gov
NCT04718350LEVOSIMENDANClinicalTrials.gov

NIH grants 3569

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01HL113006Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling382,025NIH's project files
R01HL075619Integrative Approach to Divergent Remodeling in Thin Filament Cardiomyopathies252,025NIH's project files
R01HL130020Elucidating Mechanism of Cardiac Fibrosis with Cell Village of Pooled Human iPSCs222,025NIH's project files
R01HL076485Engineering Vascularized Cardiac Muscle142,025NIH's project files
T32HL007024Cardiovascular Epidemiology Institutional Training142,025NIH's project files
P01HL141084Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology132,025NIH's project files
T32EB009035Multi-Disciplinary Training Program in Cardiovascular Imaging at Stanford132,025NIH's project files
T32HL094274Training in Myocardial Biology at Stanford122,025NIH's project files
R01HL105826Fast myosin binding protein-C and cardiac contractility in heart failure112,025NIH's project files
T32HL007572Research Methods in Pediatric Cardiovascular Disease112,025NIH's project files

Papers 10023

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42819891PubTator, text miningPubMed
42812170PubTator, text miningPubMed
42808506PubTator, text miningPubMed
42805449PubTator, text miningPubMed
42796381PubTator, text miningPubMed
42791057PubTator, text miningPubMed
42790282PubTator, text miningPubMed
42783052PubTator, text miningPubMed
42779549PubTator, text miningPubMed
42755451PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license