Gene · 715
C1R: complement C1r
12 sourcesgene-search-2026-11-11-0.2.0
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ConductScience Library. C1R: complement C1r. Genes, record 715. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/715
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Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P00736 | Complement C1r subcomponent | 705 | 12 | GeneID, HGNC |
Source UniProt
Patents10
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2025529142 A | 2025-09-04 | 5671 | P00736 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 5671 | P00736 | Espacenet |
| KR 1020240108836 A | 2024-07-10 | 17 | P00736 | Espacenet |
| US 11835530 B2 | 2023-12-05 | 4 | P00736 | Espacenet |
| US 10928402 B2 | 2021-02-23 | 4 | P00736 | Espacenet |
| WO 2020043864 A1 | 2020-03-05 | 340 | P00736 | Espacenet |
| EP 3609522 A2 | 2020-02-19 | 9 | P00736 | Espacenet |
| EP 3571222 A1 | 2019-11-27 | 5 | P00736 | Espacenet |
| JP 2017518514 A | 2017-07-06 | 326 | P00736 | Espacenet |
| EP 3142680 A2 | 2017-03-22 | 29 | P00736 | Espacenet |
Drugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,659
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | C1R papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 7 | 2025 |
| P30CA051008 | Georgetown University Lombardi Comprehensive Cancer Center Support Grant | 5 | 2025 |
| ZIAHL006223 | The role of the intracellular complement system - the complosome - in Th1 biology | 5 | 2025 |
| P30CA046934 | University of Colorado Cancer Center Support Grant | 4 | 2025 |
| R01DK076690 | Complement-mediated injury of the kidney: New mechanisms and novel therapies | 4 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 4 | 2025 |
| ZIADK075149 | Unravelling immunoregulatory circuits of tissue inflammation | 4 | 2025 |
| P30CA014520 | UW Comprehensive Cancer Center Support | 3 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 3 | 2025 |
| P30GM124169 | ALS Efficiently Networking Advanced Beam Line Experiments (ALS-ENABLE) | 3 | 2025 |
1 to 10 of 1,659Source NIH's project files
See all 1,659 nih grantsPapers2,917
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Multi-omics analyses demonstrate complement dysregulation is involved in focal segmental glomerulosclerosis. | Front Immunol | 2026 | 42780117 | PubTator, text mining | PubMed |
| Complement expression profiles in human glomerular mesangial cells, endothelial cells, podocytes and proximal tubular epithelial cells. | Front Immunol | 2026 | 42746023 | PubTator, text mining | PubMed |
| Shared dysregulation of complement and phosphorylation pathways in the cerebrospinal fluid of encephalitis, Aicardi-Goutières syndrome, and autism. | Dev Med Child Neurol | 2026 | 42615359 | PubTator, text mining | PubMed |
| Plasma Proteomic Signatures in Alkaptonuria. | Biology (Basel) | 2026 | 42589138 | PubTator, text mining | PubMed |
| C1R suppresses hepatocellular carcinoma cell aggressiveness through promoting HIF-1α degradation and modulating cuproptosis-related protein expression. | Int Immunopharmacol | 2026 | 42561667 | PubTator, text mining | PubMed |
| Plasma Extracellular Vesicles-Derived Complement Proteins as Biomarkers of Sarcopenia Progression in Longitudinal Cohorts. | J Cachexia Sarcopenia Muscle | 2026 | 42477892 | PubTator, text mining | PubMed |
| Complement dysregulation during the early phases of synucleinopathy. | Acta Neuropathol | 2026 | 42477211 | PubTator, text mining | PubMed |
| Common and rare variants in complement genes as biomarkers of COVID-19 infection and severity. A lesson to learn for emerging pathogens. | Front Immunol | 2026 | 42367796 | PubTator, text mining | PubMed |
| Serum complement system activation in normal healing and atrophic non-union of human long bone fractures. | Front Immunol | 2026 | 42344890 | PubTator, text mining | PubMed |
| Modulation of NF-κB and TLR Signaling Pathways and Complement Components in Ovine Maternal Thyroid During Early Pregnancy. | Int J Mol Sci | 2026 | 42278321 | PubTator, text mining | PubMed |
1 to 10 of 2,917
See all 2,917 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/715
GET https://conductscience.org/api/genes/v1/715/grants?page=2