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Gene · 7155

Papers2,315

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Contribution of topoisomerase IIα chromatin-tether and C-terminal domain to mitotic chromosome association and structural organization.J Cell Sci202642817708PubTator, text miningPubMed
JP-1302 inhibits RNA polymerase I transcription and induces nucleolar stress in cancer cell lines.Cell Death Discov202642816485PubTator, text miningPubMed
Integrated Experimental and Computational Investigation of Salicylaldehyde-Derived Imine/Amine Derivatives as Antioxidant and Cytotoxic Agents.Materials (Basel)202642795203PubTator, text miningPubMed
Novel Lomefloxacin-Triazole Hybrids: Design, Synthesis and In Vitro Antiproliferative Activity in Breast, Melanoma and Colon Cancer Cell Lines.Biomolecules202642793155PubTator, text miningPubMed
DNA Topoisomerase IIβ Suppresses Microglial Inflammatory Cytokine Release: A Potential Regulator of Neuroinflammation.Neurochem Res202642776333PubTator, text miningPubMed
Genetic and Molecular Determinants of Cancer Therapy-Related Cardiovascular Toxicity.Cardiovasc Toxicol202642763821PubTator, text miningPubMed
Synthesis and in silico studies of hexahydroacridine derivatives as potential antitumor agents.Sci Rep202642717215PubTator, text miningPubMed
HDAC inhibition via suberoylanilide hydroxamic acid ameliorates doxorubicin-induced cardiotoxicity.Nat Commun202642697879PubTator, text miningPubMed
Analysis of gene expression changes upon topobexin treatment and TOP2B-knockout in hiPSC-derived cardiomyocytes.Biol Open202642489567PubTator, text miningPubMed
Optimized CoQ10 delivery via ZnO/CuO nanoparticles: greater in vitro cell cycle arrest and in vivo tumor suppression than unformulated coenzyme Q10.RSC Adv202642482813PubTator, text miningPubMed
Targeting DNA topoisomerase II in Cancer: mechanism of inhibition, clinical utility, and future directions.Gene202642442624PubTator, text miningPubMed
Molecular links between reelin downregulation, topoisomerase IIβ alterations, and proteins involved in Alzheimer pathology in human SH-SY5Y neuroblastoma cell line.Exp Brain Res202642377581PubTator, text miningPubMed
Thiadiazole-4β-sulfur-demethylepipodophyllotoxin traps human topoisomerase IIβ by distorting DNA and disrupting the tyrosyl-DNA linkage.Int J Biol Macromol202642264251PubTator, text miningPubMed
The heat shock transcription factor, HSF1, stimulates the catalytic engagement of topoisomerase IIβ over topoisomerase IIα.Mol Cell202642229414PubTator, text miningPubMed
Identification of a TOP3A genetic variant as a novel biomarker for sensitivity to doxorubicin.Front Pharmacol202642212268PubTator, text miningPubMed
Deletion of TOP2B promoter using CRISPR-Cas9 induces senescence in HEK 293T cells.Biochem Biophys Rep202642211003PubTator, text miningPubMed
A53T α-Synuclein Expression is Associated with Altered Dopaminergic-Like Differentiation and Reduced DNA Topoisomerase IIβ Levels in an In Vitro Model of Parkinson's Disease.Mol Neurobiol202642113340PubTator, text miningPubMed
Integrated Global Phosphoproteomic, Bioinformatic, and Machine Learning Analysis Reveals Regulatory Networks of TOP1, TOP2A, TOP2B, and C1orf35 in Hepatocellular Carcinoma (HCC).Oncol Res202642065042PubTator, text miningPubMed
Apoptotic Induction by 1,5-Diaryl-1,4-pentadien-3-one Derivatives in the HL60 Cell Line: In Vitro and In Silico Expression.Anticancer Res202642049342PubTator, text miningPubMed
KCTD10 as a selective cancer dependency from transcription-replication conflicts (TRCs).Ageing Cancer Res Treat202642037670PubTator, text miningPubMed

gene-search-2026-11-11-0.2.0

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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