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Gene · 7155

TOP2B: DNA topoisomerase II beta

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TOP2B: DNA topoisomerase II beta. Genes, record 7155. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7155

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Gene

Symbol
TOP2B
HGNC
Name
DNA topoisomerase II beta
HGNC
NCBI Gene ID
7155
NCBI Gene
HGNC ID
HGNC:11990
HGNC
Ensembl
ENSG00000077097
NCBI Gene
Aliases
BILU, TOPIIB, top2beta
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q02880DNA topoisomerase 2-beta1,62621Ensembl, GeneID, HGNC

Source UniProt

Patents18

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-291902Q02880Espacenet
JP 2025517969 A2025-06-121902Q02880Espacenet
JP 2024123008 A2024-09-108745Q02880Espacenet
US 11446398 B22022-09-2089214Q02880Espacenet
JP 2022524081 A2022-04-27192185Q02880Espacenet
US 10501513 B22019-12-108745Q02880Espacenet
JP 2017197545 A2017-11-0233446Q02880Espacenet
US 9587003 B22017-03-078745Q02880Espacenet
US 9301993 B22016-04-058745Q02880Espacenet
US 9255129 B22016-02-098745Q02880Espacenet

1 to 10 of 18

See all 18 patents

Drugs11

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMSACRINECHEMBL43DNA topoisomerase II inhibitorINHIBITORChEMBL
BECATECARINCHEMBL2107313DNA topoisomerase II inhibitorINHIBITORChEMBL
BERUBICINCHEMBL2110580DNA topoisomerase II inhibitorINHIBITORChEMBL
BERUBICIN HYDROCHLORIDECHEMBL2103796DNA topoisomerase II inhibitorINHIBITORChEMBL
C-1311CHEMBL338604DNA topoisomerase II inhibitorINHIBITORChEMBL
DEXRAZOXANECHEMBL1738DNA topoisomerase II inhibitorINHIBITORChEMBL
DEXRAZOXANE HYDROCHLORIDECHEMBL1200778DNA topoisomerase II inhibitorINHIBITORChEMBL
ETOPOSIDECHEMBL44657DNA topoisomerase II inhibitorINHIBITORChEMBL
PAZUFLOXACINCHEMBL240163DNA topoisomerase II inhibitorINHIBITORChEMBL
TENIPOSIDECHEMBL452231DNA topoisomerase II inhibitorINHIBITORChEMBL

1 to 10 of 11

See all 11 drugs

Trials1,444

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07583550ETOPOSIDEPHASE2ClinicalTrials.gov
NCT07583511ETOPOSIDEPHASE2ClinicalTrials.gov
NCT07583511TENIPOSIDEPHASE2ClinicalTrials.gov
NCT07538271ETOPOSIDEPHASE2ClinicalTrials.gov
NCT07538258ETOPOSIDEPHASE2ClinicalTrials.gov
NCT07525466ETOPOSIDEPHASE1/PHASE2ClinicalTrials.gov
NCT07510594ETOPOSIDEPHASE2ClinicalTrials.gov
NCT07502521DEXRAZOXANEPHASE2ClinicalTrials.gov
NCT07498959ETOPOSIDEClinicalTrials.gov
NCT07497438ETOPOSIDEPHASE3ClinicalTrials.gov

1 to 10 of 1,444

See all 1,444 trials

NIH grants1,317

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTOP2B papersNewest fiscal year
P30CA016672Cancer Center Support Grant202025
ZIABC006161DNA Topoisomerases as nuclear and mitochondrial targets of Anticancer Drugs192025
P30CA006973Regional Oncology Research Center162025
ZIABC006150DNA Repair, Cell Cycle Checkpoints and Apoptosis as Targets for Anticancer Drugs162025
P30CA008748Cancer Center Support Grant132025
T32CA009582Biochemical and Chemical Training for Cancer Research132025
P30CA021765Cancer Center Support Grant (CCSG)92025
R01GM126363Mechanistic Studies of Type II Topoisomerases and Topoisomerase-Targeted Agents82025
ZIAES102765Structural Biology of Genome Maintenance and DNA repair82025
P30CA016058Cancer Center Support Grant62025

1 to 10 of 1,317Source NIH's project files

See all 1,317 nih grants

Papers2,315

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Contribution of topoisomerase IIα chromatin-tether and C-terminal domain to mitotic chromosome association and structural organization.J Cell Sci202642817708PubTator, text miningPubMed
JP-1302 inhibits RNA polymerase I transcription and induces nucleolar stress in cancer cell lines.Cell Death Discov202642816485PubTator, text miningPubMed
Integrated Experimental and Computational Investigation of Salicylaldehyde-Derived Imine/Amine Derivatives as Antioxidant and Cytotoxic Agents.Materials (Basel)202642795203PubTator, text miningPubMed
Novel Lomefloxacin-Triazole Hybrids: Design, Synthesis and In Vitro Antiproliferative Activity in Breast, Melanoma and Colon Cancer Cell Lines.Biomolecules202642793155PubTator, text miningPubMed
DNA Topoisomerase IIβ Suppresses Microglial Inflammatory Cytokine Release: A Potential Regulator of Neuroinflammation.Neurochem Res202642776333PubTator, text miningPubMed
Genetic and Molecular Determinants of Cancer Therapy-Related Cardiovascular Toxicity.Cardiovasc Toxicol202642763821PubTator, text miningPubMed
Synthesis and in silico studies of hexahydroacridine derivatives as potential antitumor agents.Sci Rep202642717215PubTator, text miningPubMed
HDAC inhibition via suberoylanilide hydroxamic acid ameliorates doxorubicin-induced cardiotoxicity.Nat Commun202642697879PubTator, text miningPubMed
Analysis of gene expression changes upon topobexin treatment and TOP2B-knockout in hiPSC-derived cardiomyocytes.Biol Open202642489567PubTator, text miningPubMed
Optimized CoQ10 delivery via ZnO/CuO nanoparticles: greater in vitro cell cycle arrest and in vivo tumor suppression than unformulated coenzyme Q10.RSC Adv202642482813PubTator, text miningPubMed

1 to 10 of 2,315

See all 2,315 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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