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TP53: tumor protein p53

1 protein, 518 patents, 10 drugs, 79 trials, 46,938 NIH grants and 285,478 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTP53HGNC
Nametumor protein p53HGNC
NCBI Gene ID7157NCBI Gene
HGNC IDHGNC:11998HGNC
EnsemblENSG00000141510NCBI Gene
AliasesBCC7, BMFS5, LFS1, P53, TRP53, p53NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P04637Cellular tumor antigen p53393318Ensembl, GeneID, HGNCUniProt

Patents 518

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4805378 A12026-09-16662P04637Espacenet
JP 2026097876 A2026-06-1640P04637Espacenet
WO 2026122568 A22026-06-111P04637Espacenet
EP 4750486 A22026-06-03121P04637Espacenet
JP 2026517823 A2026-06-0215P04637Espacenet
JP 2026515380 A2026-05-181P04637Espacenet
EP 4720111 A12026-04-081P04637Espacenet
US 12539325 B22026-02-0365P04637Espacenet
JP 2026000906 A2026-01-0669P04637Espacenet
WO 2025262023 A12025-12-2623P04637Espacenet

Drugs 10

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALRIZOMADLINCHEMBL4091801Tumour suppressor p53/oncoprotein Mdm2 inhibitorINHIBITORChEMBL
CENERSENCHEMBL2108280p53 mRNA antisense inhibitorANTISENSE INHIBITORChEMBL
CENERSEN SODIUMCHEMBL2219776p53 mRNA antisense inhibitorANTISENSE INHIBITORChEMBL
CONTUSUGENE LADENOVECCHEMBL2108585Cellular tumor antigen p53 exogenous geneEXOGENOUS GENEChEMBL
EPRENETAPOPTCHEMBL3186011Cellular tumor antigen p53 stabiliserSTABILISERChEMBL
IDASANUTLINCHEMBL2402737Tumour suppressor p53/oncoprotein Mdm2 inhibitorINHIBITORChEMBL
NAVTEMADLINCHEMBL3125702Tumour suppressor p53/oncoprotein Mdm2 inhibitorINHIBITORChEMBL
SIREMADLINCHEMBL3653256Tumour suppressor p53/oncoprotein Mdm2 inhibitorINHIBITORChEMBL
TEPRASIRANCHEMBL4297574p53 mRNA RNAi inhibitorRNAI INHIBITORChEMBL
TEPRASIRAN SODIUMCHEMBL4298179p53 mRNA RNAi inhibitorRNAI INHIBITORChEMBL

Trials 79

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06735820ALRIZOMADLINPHASE1/PHASE2ClinicalTrials.gov
NCT06654050ALRIZOMADLINPHASE2ClinicalTrials.gov
NCT06479135NAVTEMADLINPHASE3ClinicalTrials.gov
NCT05952687IDASANUTLINPHASE1ClinicalTrials.gov
NCT05797831NAVTEMADLINPHASE2/PHASE3ClinicalTrials.gov
NCT05705466NAVTEMADLINPHASE1/PHASE2ClinicalTrials.gov
NCT05701306ALRIZOMADLINPHASE1/PHASE2ClinicalTrials.gov
NCT05447663SIREMADLINPHASE1/PHASE22025-01-14ClinicalTrials.gov
NCT05180695SIREMADLINPHASE1/PHASE2ClinicalTrials.gov
NCT05155709SIREMADLINPHASE1ClinicalTrials.gov

NIH grants 46938

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant2,4512,025NIH's project files
P30CA008748Cancer Center Support Grant2,1682,025NIH's project files
P30CA006973Regional Oncology Research Center4682,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)4132,025NIH's project files
P30CA016058Cancer Center Support Grant3842,025NIH's project files
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-20283022,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant2972,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant2892,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant2652,025NIH's project files
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant2532,025NIH's project files

Papers 285478

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827381PubTator, text miningPubMed
42826913PubTator, text miningPubMed
42826912PubTator, text miningPubMed
42826872PubTator, text miningPubMed
42826715PubTator, text miningPubMed
42826064PubTator, text miningPubMed
42825943PubTator, text miningPubMed
42825276PubTator, text miningPubMed
42825038PubTator, text miningPubMed
42824783PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license