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Gene · 716

C1S: complement C1s

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. C1S: complement C1s. Genes, record 716. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/716

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Gene

Symbol
C1S
HGNC
Name
complement C1s
HGNC
NCBI Gene ID
716
NCBI Gene
HGNC ID
HGNC:1247
HGNC
Ensembl
ENSG00000182326
NCBI Gene
Aliases
EDSPD2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P09871Complement C1s subcomponent68814Ensembl, GeneID, HGNC

Source UniProt

Patents141

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4827917 A12026-10-28258P09871Espacenet
JP 2026062998 A2026-04-101P09871Espacenet
JP 2026510831 A2026-04-1065P09871Espacenet
JP 2026004568 A2026-01-1441976P09871Espacenet
JP 2026004568 A2026-01-1441977P09871Espacenet
JP 2026004568 A2026-01-1441980P09871Espacenet
WO 2025255340 A22025-12-1153P09871Espacenet
JP 2025538522 A2025-11-28258P09871Espacenet
EP 4650780 A22025-11-195759P09871Espacenet
EP 4641201 A22025-10-295423P09871Espacenet

1 to 10 of 141

See all 141 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
HUMAN C1-ESTERASE INHIBITORCHEMBL4297549Complement C1s inhibitorINHIBITORChEMBL
SUTIMLIMABCHEMBL4297832Complement C1s inhibitorINHIBITORChEMBL

Trials9

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05791708SUTIMLIMABClinicalTrials.gov
NCT05132127SUTIMLIMABPHASE32023-10-03ClinicalTrials.gov
NCT03347422SUTIMLIMABPHASE32022-12-23ClinicalTrials.gov
NCT03347396SUTIMLIMABPHASE32022-10-31ClinicalTrials.gov
NCT03275454SUTIMLIMABPHASE1ClinicalTrials.gov
NCT02865720HUMAN C1-ESTERASE INHIBITORPHASE32018-12-31ClinicalTrials.gov
NCT02502903SUTIMLIMABPHASE1ClinicalTrials.gov
NCT01843530HUMAN C1-ESTERASE INHIBITORPHASE3ClinicalTrials.gov
NCT01095497HUMAN C1-ESTERASE INHIBITORPHASE22012-03-08ClinicalTrials.gov

NIH grants1,805

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleC1S papersNewest fiscal year
P30CA008748Cancer Center Support Grant72025
R01DK076690Complement-mediated injury of the kidney: New mechanisms and novel therapies62025
ZIAHL006223The role of the intracellular complement system - the complosome - in Th1 biology52025
P30CA046934University of Colorado Cancer Center Support Grant42025
T32GM008315Mechanisms of Trauma-Induced Coagulopathy42025
UL1TR002345Washington University Institute of Clinical and Translational Sciences42025
ZIAHL006222The role of the intracellular complement system - the complosome - in monocytes42025
P20GM103418Kansas IDeA Network of Biomedical Research Excellence 532025
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant32025
P30DK123704MUSC Digestive Disease Research Core Center32025

1 to 10 of 1,805Source NIH's project files

See all 1,805 nih grants

Papers3,534

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Complement inhibition by sutimlimab in cold agglutinin disease promotes red blood cell agglutination and may lead to circulatory complications, eryptosis and hemolysis.Front Immunol202642812371PubTator, text miningPubMed
Isolated Lip Angioedema Associated With Spironolactone: A Case Report.Cureus202642802754PubTator, text miningPubMed
Multi-omics analyses demonstrate complement dysregulation is involved in focal segmental glomerulosclerosis.Front Immunol202642780117PubTator, text miningPubMed
Isolated gastrointestinal hereditary angioedema associated with a pathogenic SERPING1 variant arising de novo: a case report.Front Med (Lausanne)202642755627PubTator, text miningPubMed
Complement expression profiles in human glomerular mesangial cells, endothelial cells, podocytes and proximal tubular epithelial cells.Front Immunol202642746023PubTator, text miningPubMed
Associations between brain phenotypes and temporomandibular disorders: An integrative multi-omics investigation.Cranio202642731980PubTator, text miningPubMed
Characterising prognostic complement biomarkers during clinical normothermic machine perfusion for renal transplantation.Am J Transplant202642705465PubTator, text miningPubMed
Proteomic profiling of cephalic vein reveals potential biomarkers for arteriovenous fistula neointimal hyperplasia in ESRD patients.Ren Fail202642703036PubTator, text miningPubMed
Cold agglutinin disease: pathophysiology, diagnosis, and the evolving therapeutic landscape.Blood Res202642696222PubTator, text miningPubMed
Point-of-care assessment of complement activation in the ICU: a feasibility study of rapid terminal complement complex detection in critical illness.Front Immunol202642643423PubTator, text miningPubMed

1 to 10 of 3,534

See all 3,534 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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