Gene · 716
C1S: complement C1s
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. C1S: complement C1s. Genes, record 716. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/716
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P09871 | Complement C1s subcomponent | 688 | 14 | Ensembl, GeneID, HGNC |
Source UniProt
Patents141
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4827917 A1 | 2026-10-28 | 258 | P09871 | Espacenet |
| JP 2026062998 A | 2026-04-10 | 1 | P09871 | Espacenet |
| JP 2026510831 A | 2026-04-10 | 65 | P09871 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 41976 | P09871 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 41977 | P09871 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 41980 | P09871 | Espacenet |
| WO 2025255340 A2 | 2025-12-11 | 53 | P09871 | Espacenet |
| JP 2025538522 A | 2025-11-28 | 258 | P09871 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 5759 | P09871 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 5423 | P09871 | Espacenet |
1 to 10 of 141
See all 141 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials9
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT05791708 | SUTIMLIMAB | ClinicalTrials.gov | ||
| NCT05132127 | SUTIMLIMAB | PHASE3 | 2023-10-03 | ClinicalTrials.gov |
| NCT03347422 | SUTIMLIMAB | PHASE3 | 2022-12-23 | ClinicalTrials.gov |
| NCT03347396 | SUTIMLIMAB | PHASE3 | 2022-10-31 | ClinicalTrials.gov |
| NCT03275454 | SUTIMLIMAB | PHASE1 | ClinicalTrials.gov | |
| NCT02865720 | HUMAN C1-ESTERASE INHIBITOR | PHASE3 | 2018-12-31 | ClinicalTrials.gov |
| NCT02502903 | SUTIMLIMAB | PHASE1 | ClinicalTrials.gov | |
| NCT01843530 | HUMAN C1-ESTERASE INHIBITOR | PHASE3 | ClinicalTrials.gov | |
| NCT01095497 | HUMAN C1-ESTERASE INHIBITOR | PHASE2 | 2012-03-08 | ClinicalTrials.gov |
NIH grants1,805
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | C1S papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 7 | 2025 |
| R01DK076690 | Complement-mediated injury of the kidney: New mechanisms and novel therapies | 6 | 2025 |
| ZIAHL006223 | The role of the intracellular complement system - the complosome - in Th1 biology | 5 | 2025 |
| P30CA046934 | University of Colorado Cancer Center Support Grant | 4 | 2025 |
| T32GM008315 | Mechanisms of Trauma-Induced Coagulopathy | 4 | 2025 |
| UL1TR002345 | Washington University Institute of Clinical and Translational Sciences | 4 | 2025 |
| ZIAHL006222 | The role of the intracellular complement system - the complosome - in monocytes | 4 | 2025 |
| P20GM103418 | Kansas IDeA Network of Biomedical Research Excellence 5 | 3 | 2025 |
| P30CA051008 | Georgetown University Lombardi Comprehensive Cancer Center Support Grant | 3 | 2025 |
| P30DK123704 | MUSC Digestive Disease Research Core Center | 3 | 2025 |
1 to 10 of 1,805Source NIH's project files
See all 1,805 nih grantsPapers3,534
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Complement inhibition by sutimlimab in cold agglutinin disease promotes red blood cell agglutination and may lead to circulatory complications, eryptosis and hemolysis. | Front Immunol | 2026 | 42812371 | PubTator, text mining | PubMed |
| Isolated Lip Angioedema Associated With Spironolactone: A Case Report. | Cureus | 2026 | 42802754 | PubTator, text mining | PubMed |
| Multi-omics analyses demonstrate complement dysregulation is involved in focal segmental glomerulosclerosis. | Front Immunol | 2026 | 42780117 | PubTator, text mining | PubMed |
| Isolated gastrointestinal hereditary angioedema associated with a pathogenic SERPING1 variant arising de novo: a case report. | Front Med (Lausanne) | 2026 | 42755627 | PubTator, text mining | PubMed |
| Complement expression profiles in human glomerular mesangial cells, endothelial cells, podocytes and proximal tubular epithelial cells. | Front Immunol | 2026 | 42746023 | PubTator, text mining | PubMed |
| Associations between brain phenotypes and temporomandibular disorders: An integrative multi-omics investigation. | Cranio | 2026 | 42731980 | PubTator, text mining | PubMed |
| Characterising prognostic complement biomarkers during clinical normothermic machine perfusion for renal transplantation. | Am J Transplant | 2026 | 42705465 | PubTator, text mining | PubMed |
| Proteomic profiling of cephalic vein reveals potential biomarkers for arteriovenous fistula neointimal hyperplasia in ESRD patients. | Ren Fail | 2026 | 42703036 | PubTator, text mining | PubMed |
| Cold agglutinin disease: pathophysiology, diagnosis, and the evolving therapeutic landscape. | Blood Res | 2026 | 42696222 | PubTator, text mining | PubMed |
| Point-of-care assessment of complement activation in the ICU: a feasibility study of rapid terminal complement complex detection in critical illness. | Front Immunol | 2026 | 42643423 | PubTator, text mining | PubMed |
1 to 10 of 3,534
See all 3,534 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/716
GET https://conductscience.org/api/genes/v1/716/patents?page=2