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TPI1: triosephosphate isomerase 1

1 protein, 63 patents, 0 drugs, 0 trials, 2,302 NIH grants and 5,247 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTPI1HGNC
Nametriosephosphate isomerase 1HGNC
NCBI Gene ID7167NCBI Gene
HGNC IDHGNC:12009HGNC
EnsemblENSG00000111669NCBI Gene
AliasesHEL-S-49, TIM, TPI, TPIDNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P60174Triosephosphate isomerase24929Ensembl, GeneID, HGNCUniProt

Patents 63

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1467975P60174Espacenet
EP 4650780 A22025-11-1911418P60174Espacenet
EP 4641202 A22025-10-295963P60174Espacenet
JP 2025517970 A2025-06-1211418P60174Espacenet
KR 1020250017231 A2025-02-045963P60174Espacenet
EP 4490274 A12025-01-1531P60174Espacenet
US 11446398 B22022-09-2092225P60174Espacenet
JP 2022524081 A2022-04-27195196P60174Espacenet
US 11078247 B22021-08-0311896P60174Espacenet
JP 2019054813 A2019-04-11248410P60174Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 2302

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA006927Comprehensive Cancer Center Program at Fox Chase112,025NIH's project files
R35GM134881Studies on Enzyme Activation102,025NIH's project files
P30CA016672Cancer Center Support Grant92,025NIH's project files
P30ES013508Center of Excellence in Environmental Toxicology82,025NIH's project files
R01HD105311Developing the first TPI Df therapeutics82,025NIH's project files
P30CA008748Cancer Center Support Grant62,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)62,025NIH's project files
R01HD104346High-content screening for TPI Deficiency therapeutics62,025NIH's project files
P30CA016087Cancer Center Support Grant52,025NIH's project files
P30CA054174Mays Cancer Center at UT Health SA52,025NIH's project files

Papers 5247

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42725714PubTator, text miningPubMed
42676981PubTator, text miningPubMed
42644192PubTator, text miningPubMed
42632615PubTator, text miningPubMed
42632531PubTator, text miningPubMed
42600523PubTator, text miningPubMed
42560363PubTator, text miningPubMed
42532238PubTator, text miningPubMed
42481665PubTator, text miningPubMed
42474015PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license