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Gene · 7168

TPM1: tropomyosin 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TPM1: tropomyosin 1. Genes, record 7168. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7168

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Gene

Symbol
TPM1
HGNC
Name
tropomyosin 1
HGNC
NCBI Gene ID
7168
NCBI Gene
HGNC ID
HGNC:12010
HGNC
Ensembl
ENSG00000140416
NCBI Gene
Aliases
C15orf13, CMD1Y, CMH3, HEL-S-265, HTM-alpha, LVNC9, TMSA
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P09493Tropomyosin alpha-1 chain28414Ensembl, GeneID, HGNC

Source UniProt

Patents57

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1468323P09493Espacenet
EP 4650780 A22025-11-1911895P09493Espacenet
JP 2025529142 A2025-09-045035P09493Espacenet
US 12371689 B22025-07-295035P09493Espacenet
JP 2025517970 A2025-06-1211895P09493Espacenet
KR 1020250036258 A2025-03-1337P09493Espacenet
JP 2024109713 A2024-08-1442P09493Espacenet
US 11892452 B22024-02-06142P09493Espacenet
JP 2024009871 A2024-01-238P09493Espacenet
US 11473151 B22022-10-1842P09493Espacenet

1 to 10 of 57

See all 57 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,199

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTPM1 papersNewest fiscal year
R01HL105826Fast myosin binding protein-C and cardiac contractility in heart failure122025
R01HL036153Thin Filaments and Muscle Regulation112025
P30CA016672Cancer Center Support Grant102025
P30CA008748Cancer Center Support Grant72025
R01HL132401Mechanisms and Therapeutic Targeting of DNA Damage in Dilated Cardiomyopathy Caused by LMNA Mutations72025
R01HL136590Computational Pipeline for Identification of Disease-Causing Variants in Genes of the Cardiac Sarcomere72025
UL1TR001863Yale Clinical and Translational Science Award62025
P30CA016058Cancer Center Support Grant52025
R01HL075619Integrative Approach to Divergent Remodeling in Thin Filament Cardiomyopathies52025
T32HL007936Training Program in Translational Cardiovascular Science52025

1 to 10 of 2,199Source NIH's project files

See all 2,199 nih grants

Papers3,419

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Statement of Retraction: Long non-coding RNA MEG3 suppresses the development of bladder urothelial carcinoma by regulating miR-96 and TPM1.Cancer Biol Ther202642808420PubTator, text miningPubMed
Clinical Characteristics and Outcomes of Hypertrophic Cardiomyopathy Associated With Thin Filament Variants: Insights From the SHaRe Registry.Circ Genom Precis Med202642779549PubTator, text miningPubMed
The I130V and S229F Tropomyosin Mutations Associated With Congenital Heart Disease Disrupt Actin-Myosin Interactions in the Atria.Cytoskeleton (Hoboken)202642770678PubTator, text miningPubMed
A novel missense mutation in tropomyosin 1 gene associated with hypertrophic cardiomyopathy.J Genet Eng Biotechnol202642749423PubTator, text miningPubMed
SGLT2 inhibition improves sarcomere contractile dysfunction in human models of dilated cardiomyopathy.J Transl Med202642601625PubTator, text miningPubMed
Integrating single-cell and bulk RNA data to explore the prognostic significance of LIM domain family genes in colorectal cancer and unveil their immune landscape.Transl Oncol202642585889PubTator, text miningPubMed
Molecular Basis of Sarcomeric Variants and the Modifying Role of Non-sarcomeric Genes in Sudden Unexplained Nocturnal Death Syndrome (SUNDS).J Mol Diagn202642480850PubTator, text miningPubMed
Functional Pulmonary Atresia With Overlapping Dilated, Hypertrophic, and Excessive Trabeculation Cardiomyopathy in a Neonate With a TPM1 Mutation.CJC Pediatr Congenit Heart Dis202642422415PubTator, text miningPubMed
The effects of two Leu-to-Pro substitutions, L57P and L43P, on structural and functional properties of cardiac tropomyosin.FEBS J202642411149PubTator, text miningPubMed
[A novel TPM1 variant causing Dilated cardiomyopathy in a child: A case report and literature review].Zhonghua Yi Xue Yi Chuan Xue Za Zhi202642386664PubTator, text miningPubMed

1 to 10 of 3,419

See all 3,419 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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