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Gene · 7169

TPM2: tropomyosin 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TPM2: tropomyosin 2. Genes, record 7169. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7169

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Gene

Symbol
TPM2
HGNC
Name
tropomyosin 2
HGNC
NCBI Gene ID
7169
NCBI Gene
HGNC ID
HGNC:12011
HGNC
Ensembl
ENSG00000198467
NCBI Gene
Aliases
AMCD1, CMYO23, CMYP23, DA1, DA2B, DA2B4, HEL-S-273, NEM4, TMSB
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P07951Tropomyosin beta chain2840Ensembl, GeneID, HGNC

Source UniProt

Patents33

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1468328P07951Espacenet
EP 4650780 A22025-11-1919531P07951Espacenet
JP 2025517970 A2025-06-1219531P07951Espacenet
US 11446398 B22022-09-2093000P07951Espacenet
JP 2022524081 A2022-04-27195971P07951Espacenet
JP 2019054813 A2019-04-11248763P07951Espacenet
JP 2017121241 A2017-07-13248763P07951Espacenet
JP 2016507723 A2016-03-10175P07951Espacenet
EP 2926138 A22015-10-07175P07951Espacenet
KR 1020150090240 A2015-08-05175P07951Espacenet

1 to 10 of 33

See all 33 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants940

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTPM2 papersNewest fiscal year
ZIANS003129Molecular and Clinical Manifestations of Matrix and Aggregate Myopathies82025
P30CA008748Cancer Center Support Grant72025
R01AR053897Roles of Nebulin in Structure and Function of Striated Muscle62025
P50HD103525WASHINGTON UNIVERSITY INTELLECTUAL AND DEVELOPMENTAL DISABILITIES RESEARCH CENTER42025
UL1TR002345Washington University Institute of Clinical and Translational Sciences42025
P20GM103432Wyoming IDeA Networks for Biomedical Research Excellence Phase 432025
P30CA016672Cancer Center Support Grant32025
R01AR068128Mechanisms and Function of Myonuclear Positioning32025
R01HL105826Fast myosin binding protein-C and cardiac contractility in heart failure32025
R35GM139517Computational- and experimental- driven discovery of splicing regulation and circRNA function32025

1 to 10 of 940Source NIH's project files

See all 940 nih grants

Papers1,629

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Fibroblast-associated TPM2 links cell-matrix remodeling to EMT-Notch signaling and gemcitabine resistance in intrahepatic cholangiocarcinoma.Cancer Biol Ther202642766730PubTator, text miningPubMed
Single-cell transcriptomics deciphers cancer-associated fibroblast heterogeneity and immune regulatory mechanisms in the bladder cancer tumor microenvironment.Front Cell Dev Biol202642729537PubTator, text miningPubMed
Discovery of DA1 as PARP inhibitor for the treatment of BRCA-proficient triple negative breast cancer by suppressing the PI3K/AKT/mTOR signaling pathway.Bioorg Med Chem202642531674PubTator, text miningPubMed
Clinical and Molecular Heterogeneity of MYH3-Related Arthrogryposis with a Novel MYH3 Variant.Genes (Basel)202642510802PubTator, text miningPubMed
Disease-associated mutations in TPM2 alter regulation of actin filament stability and cofilin-dependent dynamics.bioRxiv202642239403PubTator, text miningPubMed
Protein expression profiling of lenvatinib-resistant liver cancer cells and identify B4GALT4 as a critical drug resistance molecule.Discov Oncol202642091754PubTator, text miningPubMed
Dynamic immune landscape of NAFLD highlights pDCs as predictive biomarkers for disease progression.Front Immunol202642039185PubTator, text miningPubMed
Peptide-drug conjugates bearing an antimitotic Ahx-DA1 payload achieve potent antitumor activity in Her2-amplified and EGFR-positive KRAS-mutant cancers in vivo.Bioorg Med Chem202642033924PubTator, text miningPubMed
Spatial Robustness of Prostate Cancer Biomarkers Evaluated by Spatial Transcriptomics.Prostate202641911496PubTator, text miningPubMed
Integrated transcriptomics and proteomics analysis reveal potential target in pediatric primary restrictive cardiomyopathy.Pediatr Res202641876697PubTator, text miningPubMed

1 to 10 of 1,629

See all 1,629 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7169

GET https://conductscience.org/api/genes/v1/7169/patents?page=2