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Gene · 717

C2: complement C2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. C2: complement C2. Genes, record 717. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/717

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Gene

Symbol
C2
HGNC
Name
complement C2
HGNC
NCBI Gene ID
717
NCBI Gene
HGNC ID
HGNC:1248
HGNC
Ensembl
ENSG00000166278
NCBI Gene
Aliases
ARMD14, CO2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P06681Complement C275214Ensembl, GeneID, HGNC

Source UniProt

Patents119

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026515744 A2026-05-19121P06681Espacenet
JP 2026004568 A2026-01-1441983P06681Espacenet
JP 2026004568 A2026-01-1441985P06681Espacenet
JP 2026004568 A2026-01-1441987P06681Espacenet
JP 2026004568 A2026-01-1441989P06681Espacenet
JP 2026004568 A2026-01-1441993P06681Espacenet
JP 2026004568 A2026-01-1441997P06681Espacenet
JP 2026004568 A2026-01-1442022P06681Espacenet
WO 2025257157 A12025-12-181P06681Espacenet
WO 2025238225 A12025-11-201P06681Espacenet

1 to 10 of 119

See all 119 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,292

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleC2 papersNewest fiscal year
P30EY014800University of Utah Core Vision Research Grant72025
K12EY016335Harvard-Vision Clinical Scientist Development Program62025
P30EY014801Miami Center for Vision Research62025
R01EY022445Use of Correlated Data Methods in Ophthalmology52025
R01AI024717Genetic Linkage in Lupus42025
I01RX000444Complement Factor H-based Therapeutic Strategies in Macular Degeneration32025
P30CA008748Cancer Center Support Grant32025
P30DK063491Diabetes Research Center (DRC)32025
K08AR081412Architecture and interactions of Granzyme K+ CD8 T cells in inflamed synovium in rheumatoid arthritis22025
P01AI148102Differentiation of immune cells and fibrobalsts in inflamed tissue in RA and SLE22025

1 to 10 of 1,292Source NIH's project files

See all 1,292 nih grants

Papers2,431

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Cobalt-mediated suppression of IFN-γ-JAK-STAT1 signaling reprograms IDO1-driven immunosuppression for metalloimmunotherapy.Sci Adv202642758828PubTator, text miningPubMed
Plasma protein profile in patients with antiphospholipid syndrome and controls without antiphospholipid syndrome.J Thromb Haemost202642674367PubTator, text miningPubMed
Systematic review of extracellular vesicle-based liquid biopsy for leptomeningeal metastasis: current evidence and future directions.Clin Exp Metastasis202642484930PubTator, text miningPubMed
Apnea Testing for Brain Death/Death by Neurologic Criteria in Adults: A Prospective Multicenter Observational Study Assessing the Relationship Between Methodology, Safety, and Duration.Crit Care Explor202642390295PubTator, text miningPubMed
Investigation of metal identity on the structure and electronic properties of dinuclear Mn and Co complexes with triaryl tetradentate ligands.Dalton Trans202642300565PubTator, text miningPubMed
Ultra-hydrophilic MXene nanoplatform unraveling plasma N-glycopeptide in epidural-related maternal fever.Mikrochim Acta202642277438PubTator, text miningPubMed
Aptamers with magnetically tunable affinity for divalent cobalt ions.Nat Commun202641851151PubTator, text miningPubMed
CSL305: A Dual Functional Therapeutic Antibody Targeting Complement C2 and FcRn.Int J Mol Sci202641828601PubTator, text miningPubMed
Iron, arginine, and redox metabolism in peripheral blood mononuclear cells distinguishes sickle cell disease and pulmonary hypertension.Hemasphere202641799249PubTator, text miningPubMed
The mitogenome mutation repertoire affects progression of Parkinson's Disease.Genet Mol Biol202641790955PubTator, text miningPubMed

1 to 10 of 2,431

See all 2,431 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/717

GET https://conductscience.org/api/genes/v1/717/patents?page=2