Gene · 7170
TPM3: tropomyosin 3
12 sourcesgene-search-2026-11-11-0.2.0
Download JSON
Cite this record
ConductScience Library. TPM3: tropomyosin 3. Genes, record 7170. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7170
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P06753 | Tropomyosin alpha-3 chain | 285 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents17
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4698223 A2 | 2026-02-25 | 20 | P06753 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 68336 | P06753 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 37515 | P06753 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 37515 | P06753 | Espacenet |
| EP 4373841 A1 | 2024-05-29 | 54 | P06753 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 37515 | P06753 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 93010 | P06753 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 195981 | P06753 | Espacenet |
| JP 2020508652 A | 2020-03-26 | 37515 | P06753 | Espacenet |
| WO 2020043864 A1 | 2020-03-05 | 2667 | P06753 | Espacenet |
1 to 10 of 17
See all 17 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,008
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TPM3 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 56 | 2025 |
| ZIANS003129 | Molecular and Clinical Manifestations of Matrix and Aggregate Myopathies | 12 | 2025 |
| P30CA046934 | University of Colorado Cancer Center Support Grant | 9 | 2025 |
| ZIANS003139 | Computational studies of membrane transport proteins | 9 | 2025 |
| K12CA086913 | Paul Calabresi Award in Clinical Oncology Research | 8 | 2025 |
| R01MH054137 | Structure and Function of Dopamine Receptors | 8 | 2025 |
| R35GM128641 | Structure, pharmacology and signaling of G protein-coupled receptors (GPCRs) in inflammation | 8 | 2025 |
| ZIADK031126 | Computer Modeling of G Protein-Coupled Receptors | 8 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 7 | 2025 |
| R01AR053897 | Roles of Nebulin in Structure and Function of Striated Muscle | 7 | 2025 |
1 to 10 of 2,008Source NIH's project files
See all 2,008 nih grantsPapers3,595
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Diffuse Eruptive Spitz Nevus With Somatic TPM3::ALK Fusion Confirmed Across Anatomically Distinct Lesions. | Pigment Cell Melanoma Res | 2026 | 42827359 | PubTator, text mining | PubMed |
| A chemoresistance-associated proliferation gene signature identified by single-cell and machine learning analysis predicts prognosis in high-grade serous ovarian carcinoma. | Transl Oncol | 2026 | 42696959 | PubTator, text mining | PubMed |
| Adult Sarcomas with NTRK Fusions: Clinicopathologic and Genomic Heterogeneity. | Cancers (Basel) | 2026 | 42588743 | PubTator, text mining | PubMed |
| Longitudinal Molecular Characterization of a Rare TPM3::PDGFRB-Rearranged Myeloid/Lymphoid Neoplasm With Late CNL-Like Neutrophilic Evolution. | Eur J Haematol | 2026 | 42549531 | PubTator, text mining | PubMed |
| Research progress on the role and mechanism of STIM and Orai protein-mediated store-operated calcium entry in cardiovascular diseases. | Channels (Austin) | 2026 | 42503223 | PubTator, text mining | PubMed |
| Distinct conformational dynamics of the type-2 Angiotensin II receptor bound to Angiotensin II and Angiotensin (1-7). | Sci Rep | 2026 | 42477346 | PubTator, text mining | PubMed |
| Evolutionarily conserved hydrophobicity and sterics in TM3/TM4 balance Orai1 pore opening. | Protein Sci | 2026 | 42438363 | PubTator, text mining | PubMed |
| Cancer of Unknown Primary Most Suggestive of Colorectal Origin With Microsatellite Instability-high Status and High Tumor Mutation Burden Including NTRK Fusion. | Cancer Diagn Progn | 2026 | 42388581 | PubTator, text mining | PubMed |
| In vitro and in silico modelling of ROS1-positive non-small cell lung cancer reveals fusion-dependent tyrosine kinase inhibitor responses. | Mol Oncol | 2026 | 42338217 | PubTator, text mining | PubMed |
| Structural basis for lysophosphatidic acid recognition and atypical Gαq coupling by LPAR5. | Proc Natl Acad Sci U S A | 2026 | 42313925 | PubTator, text mining | PubMed |
1 to 10 of 3,595
See all 3,595 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/7170
GET https://conductscience.org/api/genes/v1/7170/patents