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Gene · 7172

TPMT: thiopurine S-methyltransferase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TPMT: thiopurine S-methyltransferase. Genes, record 7172. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7172

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Gene

Symbol
TPMT
HGNC
Name
thiopurine S-methyltransferase
HGNC
NCBI Gene ID
7172
NCBI Gene
HGNC ID
HGNC:12014
HGNC
Ensembl
ENSG00000137364
NCBI Gene
Aliases
TPMTD
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P51580Thiopurine S-methyltransferase2452Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1466949P51580Espacenet
EP 4650780 A22025-11-194824P51580Espacenet
EP 4640849 A22025-10-29662P51580Espacenet
EP 4641201 A22025-10-294395P51580Espacenet
JP 2025519096 A2025-06-24662P51580Espacenet
JP 2025517969 A2025-06-124395P51580Espacenet
JP 2025517970 A2025-06-124824P51580Espacenet
EP 4484957 A12025-01-0180P51580Espacenet
WO 2023162878 A2023-08-3180P51580Espacenet
US 11446398 B22022-09-2088350P51580Espacenet

1 to 10 of 28

See all 28 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants970

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTPMT papersNewest fiscal year
P30CA021765Cancer Center Support Grant (CCSG)802025
U01HG006379EHR-based Genomic Discovery and Implementation [Funded Extension]92025
U10CA180886COG NCTN Network Group Operations Center - Year 11 STAR Act MCI and PEC Supplement92025
U10CA180899Children's Oncology Group Statistics and Data Center92025
R35GM141947Pharmacogenetics of Nucleobase and Nucleoside Analog Drugs82025
U24HG010615PharmGKB82025
ZIABC010627Clinical Pharmacogenetics82025
P30CA014599Cancer Center Support Grant72025
T32GM007569Clinical Pharmacology Training Program72025
UG1CA189955Children's Oncology Group NCI Community Oncology Research Program (NCORP) Research Base grant72025

1 to 10 of 970Source NIH's project files

See all 970 nih grants

Papers3,004

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
TPMT and NUDT15 Pharmacogenomic Profiles in Peruvian Patients With Pediatric Hematologic Malignancies.Front Biosci (Schol Ed)202642812040PubTator, text miningPubMed
Lead exposure decreases TPMT activity, highlighting the need for thiopurine dose adjustment in high-exposure individuals.J Trace Elem Med Biol202642753434PubTator, text miningPubMed
Impact of genetic polymorphisms on the response to transdermal fentanyl in cancer patients-a single-center, prospective, biological study.Front Pain Res (Lausanne)202642676478PubTator, text miningPubMed
Prognostic value of different sarcopenia assessment methods for mortality in patients with liver cirrhosis: a systematic review and meta-analysis.Front Nutr202642661677PubTator, text miningPubMed
Pharmacogenetic Predictors of Chemotherapy Treatment-Related Toxicities in Paediatric and Adolescent Acute Lymphoblastic Leukemia: A Systematic Review, Meta-Analysis and Literature-Based Candidate Prioritization.
Pharmaceuticals (Basel)202642653702PubTator, text miningPubMed
Flype: Integrating Molecular and Pharmacogenomic Results to Enhance Oncology Patient Care in a Community-Based Academic Cancer Center.Cancers (Basel)202642649875PubTator, text miningPubMed
A PRISMA-guided systematic review of pharmacogenetic anticancer clinical trials registered on clinicaltrials.gov.Medicine (Baltimore)202642601762PubTator, text miningPubMed
Identification and validation of mitophagy and astrocyte-related molecular signature in the pathogenesis of Alzheimer's disease: evidence from ensemble learning-driven multi-omics and clinical validation.
Front Neurosci202642568632PubTator, text miningPubMed
Clinical Functional Assignment of TPMT and NUDT15 Alleles by the Clinical Pharmacogenetics Implementation Consortium Pharmacogene Curation Expert Panel.Clin Pharmacol Ther202642560154PubTator, text miningPubMed
Pharmacogenomic biomarkers in oncology: evidence, clinical utility, and barriers to implementation.J Chemother202642560047PubTator, text miningPubMed

1 to 10 of 3,004

See all 3,004 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7172

GET https://conductscience.org/api/genes/v1/7172/patents?page=2