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TPO: thyroid peroxidase

1 protein, 107 patents, 3 drugs, 32 trials, 4,145 NIH grants and 18,883 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTPOHGNC
Namethyroid peroxidaseHGNC
NCBI Gene ID7173NCBI Gene
HGNC IDHGNC:12015HGNC
EnsemblENSG00000115705NCBI Gene
AliasesMSA, TDH2A, TPXNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P07202Thyroid peroxidase9330Ensembl, GeneID, HGNCUniProt

Patents 107

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4824265 A12026-10-2111P07202Espacenet
JP 2026004568 A2026-01-1467088P07202Espacenet
JP 2026004568 A2026-01-1467090P07202Espacenet
EP 4670794 A22025-12-3128P07202Espacenet
US 12502436 B22025-12-234695P07202Espacenet
JP 2025181835 A2025-12-114695P07202Espacenet
EP 4650780 A22025-11-195214P07202Espacenet
EP 4641201 A22025-10-294799P07202Espacenet
JP 2025147176 A2025-10-0613682P07202Espacenet
JP 2025147176 A2025-10-0613683P07202Espacenet

Drugs 3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CARBIMAZOLECHEMBL508102Thyroid peroxidase inhibitorINHIBITORChEMBL
METHIMAZOLECHEMBL1515Thyroid peroxidase inhibitorINHIBITORChEMBL
PROPYLTHIOURACILCHEMBL1518Thyroid peroxidase inhibitorINHIBITORChEMBL

Trials 32

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07369063METHIMAZOLEPHASE2ClinicalTrials.gov
NCT07040306METHIMAZOLEClinicalTrials.gov
NCT06570967METHIMAZOLEClinicalTrials.gov
NCT06068179METHIMAZOLEPHASE2/PHASE3ClinicalTrials.gov
NCT05964452METHIMAZOLEClinicalTrials.gov
NCT05762146PROPYLTHIOURACILPHASE2ClinicalTrials.gov
NCT05607407METHIMAZOLEPHASE2ClinicalTrials.gov
NCT05118542METHIMAZOLEPHASE3ClinicalTrials.gov
NCT05118542PROPYLTHIOURACILPHASE3ClinicalTrials.gov
NCT05043233METHIMAZOLEClinicalTrials.gov

NIH grants 4145

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant682,025NIH's project files
R01DK015070Thyroid Physiology Studies of Inherited Disorders222,025NIH's project files
P30CA016672Cancer Center Support Grant202,025NIH's project files
R01DK067555Analyzing Genes for Autoimmune Thyroiditis and Diabetes: Translation to Therapy142,025NIH's project files
ZIABC005522Thyroid regeneration and carcinogenesis122,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)112,025NIH's project files
P01CA108671Myeloproliferative Neoplasms-Research Consortium102,025NIH's project files
P30CA015704Cancer Center Support Grant102,025NIH's project files
P51OD011106Wisconsin National Primate Research Center Support102,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award92,025NIH's project files

Papers 18883

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827343PubTator, text miningPubMed
42827086PubTator, text miningPubMed
42824004PubTator, text miningPubMed
42818866PubTator, text miningPubMed
42811826PubTator, text miningPubMed
42808110PubTator, text miningPubMed
42799046PubTator, text miningPubMed
42797344PubTator, text miningPubMed
42792685PubTator, text miningPubMed
42792144PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license