Gene · 7175
TPR: translocated promoter region, nuclear basket protein
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TPR: translocated promoter region, nuclear basket protein. Genes, record 7175. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7175
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P12270 | Nucleoprotein TPR | 2,363 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents21
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 67717 | P12270 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 8239 | P12270 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 8412 | P12270 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 8412 | P12270 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 8239 | P12270 | Espacenet |
| JP 2024525512 A | 2024-07-12 | 16 | P12270 | Espacenet |
| KR 1020240027814 A | 2024-03-04 | 16 | P12270 | Espacenet |
| JP 2022141755 A | 2022-09-29 | 755 | P12270 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 90545 | P12270 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 193516 | P12270 | Espacenet |
1 to 10 of 21
See all 21 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,079
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TPR papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 30 | 2025 |
| P30CA014195 | Cancer Center Support Grant (CCSG) | 7 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 6 | 2025 |
| P30CA042014 | Cancer Center Support Grant | 6 | 2025 |
| R01GM112108 | Structure-Function Mapping of the Nuclear Pore Complex-Renewal | 6 | 2025 |
| R35GM122552 | Super-resolution Microscopy Study of Molecular Transport Mechanisms | 6 | 2025 |
| P30CA030199 | Cancer Center Support Grant (CCSG) | 4 | 2025 |
| R01CA080728 | Oncogenic Impact of eIF4E-dependent RNA Export in Cancer | 4 | 2025 |
| ZIAHD008954 | Mitotic roles of the Nuclear Transport Machinery | 4 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 3 | 2025 |
1 to 10 of 1,079Source NIH's project files
See all 1,079 nih grantsPapers1,702
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| [Syphilis and human treponemes: a long evolutionary history revealed by paleogenomics]. | Med Sci (Paris) | 2026 | 42735346 | PubTator, text mining | PubMed |
| From the TPR pathway and the neuroimmune unit to the cutaneous HPA axis: a neuro-endo-immune cross-talk in rosacea. | Front Med (Lausanne) | 2026 | 42577786 | PubTator, text mining | PubMed |
| Domain-dependent uncoupling of the co-chaperone and E3 ubiquitin ligase CHIP underlies heterogeneity in spinocerebellar ataxia 48. | J Biol Chem | 2026 | 42567515 | PubTator, text mining | PubMed |
| O-GlcNAc transferase as an oncogenic regulator in hematologic malignancies: Mechanisms, disease contexts, and therapeutic perspectives. | Biomed Pharmacother | 2026 | 42546407 | PubTator, text mining | PubMed |
| A novel optically gated thin-film transistor sensor for real-time chemical differentiation using machine-learning analysis. | Biosens Bioelectron X | 2026 | 42416781 | PubTator, text mining | PubMed |
| Norlichexanthone, a shunt product of Griseofulvin, disrupts spindle assembly checkpoint and nucleocytoplasmic transport by targeting TPR in the nuclear pore complex. | Bioorg Chem | 2026 | 42330849 | PubTator, text mining | PubMed |
| Nucleoporin TPR integrates MAPK signaling with mitogen-induced transcriptional programs. | Cell Death Dis | 2026 | 42031697 | PubTator, text mining | PubMed |
| Catalyst-Free, Divergent Cysteine Modification via Indole Isocyanide Photochemistry. | Angew Chem Int Ed Engl | 2026 | 42027049 | PubTator, text mining | PubMed |
| STUB1-VCP/p97 limits PINK1 overaccumulation to safeguard mitophagy and memory. | Autophagy | 2026 | 41964371 | PubTator, text mining | PubMed |
| Validation of a Risk-Prediction Model in the Presence of Outcome Misclassification. | Stat Med | 2026 | 41930736 | PubTator, text mining | PubMed |
1 to 10 of 1,702
See all 1,702 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/7175
GET https://conductscience.org/api/genes/v1/7175/patents?page=2