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Gene · 7178

TPT1: tumor protein, translationally-controlled 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TPT1: tumor protein, translationally-controlled 1. Genes, record 7178. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7178

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Gene

Symbol
TPT1
HGNC
Name
tumor protein, translationally-controlled 1
HGNC
NCBI Gene ID
7178
NCBI Gene
HGNC ID
HGNC:12022
HGNC
Ensembl
ENSG00000133112
NCBI Gene
Aliases
HRF, TCTP, fortilin, p02, p23
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P13693Translationally-controlled tumor protein1728Ensembl, GeneID, HGNC

Source UniProt

Patents91

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1468726P13693Espacenet
EP 4650780 A22025-11-1915463P13693Espacenet
EP 4641202 A22025-10-297580P13693Espacenet
JP 2025517970 A2025-06-1215463P13693Espacenet
EP 4553087 A12025-05-14189P13693Espacenet
JP 2025032204 A2025-03-1137531P13693Espacenet
KR 1020250017231 A2025-02-047580P13693Espacenet
EP 4461818 A22024-11-1337531P13693Espacenet
US 12024722 B22024-07-02149P13693Espacenet
KR 1020240006464 A2024-01-1582P13693Espacenet

1 to 10 of 91

See all 91 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants839

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTPT1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant92025
R35GM126945Mechanisms of DNA and RNA Transactions72025
P30CA016672Cancer Center Support Grant42025
P30CA016086Cancer Center Support Grant32025
T32ES018827Research Training in Environmental Toxicology32025
P20GM103408Idaho INBRE Program22025
P30CA015704Cancer Center Support Grant22025
P30CA023108Cancer Center Support Grant22025
P30CA030199Cancer Center Support Grant (CCSG)22025
P30CA046934University of Colorado Cancer Center Support Grant22025

1 to 10 of 839Source NIH's project files

See all 839 nih grants

Papers1,918

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Extracellular vesicles shape tumourigenesis: from signalling networks to systemic progression.Cancer Metastasis Rev202642776258PubTator, text miningPubMed
Assessment of USP17 and TPT1 Expression in Primary and Matched Metastatic Tissue of Patients with High-Grade Serous Ovarian Carcinoma and the Relationship to Distant Metastasis.Diagnostics (Basel)202642739136PubTator, text miningPubMed
2''F-NAD+ is a broad-spectrum RNA 2'-phosphotransferase (Tpt1) poison that traps the enzyme on its abortive RNA-2'-phospho-(2''F-ADP-ribose) reaction intermediate.RNA202642692819PubTator, text miningPubMed
Enrofloxacin's dual effects on earthworms: Reproductive toxicity at environmental levels and growth promotion at elevated concentrations.J Environ Sci (China)202642680393PubTator, text miningPubMed
Engineering TPT1-mediated apoptosis resistance for improved mammalian cell biomanufacturing.Metab Eng202642674249PubTator, text miningPubMed
Non-invasive differentiation between aplastic anemia and myelodysplastic syndromes based on an 8-feature lightGBM model: A multicenter external validation study.Curr Res Transl Med202642485818PubTator, text miningPubMed
Multi-level biomarker responses in Eisenia fetida co-exposed to PE-MPs and DiBP: An ecological risk assessment based on physiological, biochemical, and molecular indicators.Comp Biochem Physiol C Toxicol Pharmacol202642442648PubTator, text miningPubMed
Reproductive toxicity effects and mechanisms of perfluorobutane sulfonate on the Clitellum in Eisenia fetida: Insights from histopathology, multi-omics and biomarker analyses.Ecotoxicol Environ Saf202642361666PubTator, text miningPubMed
Single-cell analysis of skin and blood reveals systemic immune responses to ultraviolet B and their impairment in MS.J Neuroinflammation202642237169PubTator, text miningPubMed
The protective role of vitamin C in diabetic retinopathy and TPT1 as a potential therapeutic target.Nutr Metab (Lond)202642121245PubTator, text miningPubMed

1 to 10 of 1,918

See all 1,918 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7178

GET https://conductscience.org/api/genes/v1/7178/patents?page=2