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C3: complement C3

1 protein, 205 patents, 3 drugs, 38 trials, 8,436 NIH grants and 31,977 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolC3HGNC
Namecomplement C3HGNC
NCBI Gene ID718NCBI Gene
HGNC IDHGNC:1318HGNC
EnsemblENSG00000125730NCBI Gene
AliasesAHUS5, ARMD9, ASP, C3a, C3b, CPAMD1, HEL-S-62pNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P01024Complement C31,66378Ensembl, GeneID, HGNCUniProt

Patents 205

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4763226 A22026-06-2447P01024Espacenet
JP 2026515744 A2026-05-19276P01024Espacenet
JP 2026067851 A2026-04-21392P01024Espacenet
EP 4716544 A22026-04-01177P01024Espacenet
US 12560619 B22026-02-24113P01024Espacenet
US 12544423 B22026-02-1018P01024Espacenet
JP 2026004568 A2026-01-1442059P01024Espacenet
EP 4650780 A22025-11-191167P01024Espacenet
EP 4640849 A22025-10-29130P01024Espacenet
EP 4641201 A22025-10-29829P01024Espacenet

Drugs 3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AL-78898ACHEMBL4594457Complement C3 inhibitorINHIBITORChEMBL
AMY-101CHEMBL4297260Complement C3 inhibitorINHIBITORChEMBL
PEGCETACOPLANCHEMBL4298211Complement C3 inhibitorINHIBITORChEMBL

Trials 38

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07495722PEGCETACOPLANPHASE1ClinicalTrials.gov
NCT07215390PEGCETACOPLANPHASE2ClinicalTrials.gov
NCT07214740PEGCETACOPLANPHASE3ClinicalTrials.gov
NCT07214298PEGCETACOPLANPHASE1/PHASE2ClinicalTrials.gov
NCT07213960PEGCETACOPLANPHASE2/PHASE3ClinicalTrials.gov
NCT07160179PEGCETACOPLANPHASE1/PHASE2ClinicalTrials.gov
NCT06722157PEGCETACOPLANPHASE2ClinicalTrials.gov
NCT06161584PEGCETACOPLANClinicalTrials.gov
NCT05809531PEGCETACOPLANPHASE3ClinicalTrials.gov
NCT05776472PEGCETACOPLANClinicalTrials.gov

NIH grants 8436

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01DK076690Complement-mediated injury of the kidney: New mechanisms and novel therapies412,025NIH's project files
R01AR051749Complement in the Pathogenesis of Autoimmune Arthritis352,025NIH's project files
P30CA008748Cancer Center Support Grant222,025NIH's project files
R01DK078244Molecular Basis of Pathogenicity of IgA1-containing Immune Complexes212,025NIH's project files
R01DK110023C3 Glomerulopathy -- A Collaborative Study212,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award202,025NIH's project files
ZIAHL006223The role of the intracellular complement system - the complosome - in Th1 biology202,025NIH's project files
P30CA016520Abramson Cancer Center Support Grant182,025NIH's project files
I01RX000444Complement Factor H-based Therapeutic Strategies in Macular Degeneration162,025NIH's project files
T32AR007279Immunobiology of the Rheumatic Diseases152,025NIH's project files

Papers 31977

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42820034PubTator, text miningPubMed
42818786PubTator, text miningPubMed
42812634PubTator, text miningPubMed
42811902PubTator, text miningPubMed
42810467PubTator, text miningPubMed
42803648PubTator, text miningPubMed
42802740PubTator, text miningPubMed
42798129PubTator, text miningPubMed
42791523PubTator, text miningPubMed
42781170PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license