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Gene · 7185

TRAF1: TNF receptor associated factor 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TRAF1: TNF receptor associated factor 1. Genes, record 7185. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7185

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Gene

Symbol
TRAF1
HGNC
Name
TNF receptor associated factor 1
HGNC
NCBI Gene ID
7185
NCBI Gene
HGNC ID
HGNC:12031
HGNC
Ensembl
ENSG00000056558
NCBI Gene
Aliases
EBI6, MGC:10353
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13077TNF receptor-associated factor 14163Ensembl, GeneID, HGNC

Source UniProt

Patents61

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1467181Q13077Espacenet
JP 2026004568 A2026-01-1467182Q13077Espacenet
EP 4650780 A22025-11-199390Q13077Espacenet
EP 4641202 A22025-10-295603Q13077Espacenet
JP 2025517970 A2025-06-129390Q13077Espacenet
JP 2025032204 A2025-03-1137547Q13077Espacenet
JP 2025032204 A2025-03-1137549Q13077Espacenet
KR 1020250017231 A2025-02-045603Q13077Espacenet
EP 4461818 A22024-11-1337547Q13077Espacenet
EP 4461818 A22024-11-1337549Q13077Espacenet

1 to 10 of 61

See all 61 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,782

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTRAF1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant152025
P30CA008748Cancer Center Support Grant52025
P30ES005605Environmental Health Sciences Research Center52025
P01CA019014Viral Oncogenesis, Latency, and Replication42025
P30CA068485Cancer Center Support Grant42025
P30CA086862Cancer Center Support Grant42025
P30CA091842Cancer Center Support Grant42025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital42025
R01CA228700Epstein-Barr virus LMP1 mediated oncogenicity42025
T32AI007061Infectious Disease and Basic Microbiological Mechanisms42025

1 to 10 of 1,782Source NIH's project files

See all 1,782 nih grants

Papers2,530

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Bioinformatics Analysis of T-cell Exhaustion Genes in Pediatric Allergic Rhinitis and their Clinical Diagnostic Significance.Endocr Metab Immune Disord Drug Targets202642813621PubTator, text miningPubMed
Shared non-HLA genetic architecture across diverse ancestries links insulin secretion and resistance to type 1 diabetes.Diabetologia202642771182PubTator, text miningPubMed
Identification of TRAF1 as a crucial regulator of inflammatory and oxidative injury in acute myocardial infarction.Pathol Res Pract202642731176PubTator, text miningPubMed
An ICD gene set-derived immune contexture signature for colorectal cancer prognosis: integrated single-cell and bulk transcriptomic analysis with external validation.Cancer Treat Res Commun202642636619PubTator, text miningPubMed
TRAF1 S146 is constitutively phosphorylated in OP9-cultured primary chronic lymphocytic leukemia cells by PKN1/2.Immunohorizons202642607300PubTator, text miningPubMed
EBV-Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma.Adv Sci (Weinh)202642603298PubTator, text miningPubMed
Tumor Necrosis Factor Receptor 1 Regulates Colonic Mesenchymal Cell Diversity and the Epithelial Stem Cell Niche.Cell Mol Gastroenterol Hepatol202642575201PubTator, text miningPubMed
Integrative Multiomics and Single-cell Profiling Identify Cell-type-resolved Inflammatory Drivers in Symptomatic Irreversible Pulpitis.J Endod202642486295PubTator, text miningPubMed
Costunolide ameliorates autoimmune uveitis by targeting USP15 to suppress TNF-α-induced retinal endothelial inflammation.Proc Natl Acad Sci U S A202642412947PubTator, text miningPubMed
Integrating chromatin accessibility and GWAS identifies RUNX3 and TRAF1 as susceptibility genes for rheumatoid arthritis.J Bone Miner Res202642275102PubTator, text miningPubMed

1 to 10 of 2,530

See all 2,530 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7185

GET https://conductscience.org/api/genes/v1/7185/patents?page=2