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Gene · 719

C3AR1: complement C3a receptor 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. C3AR1: complement C3a receptor 1. Genes, record 719. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/719

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Gene

Symbol
C3AR1
HGNC
Name
complement C3a receptor 1
HGNC
NCBI Gene ID
719
NCBI Gene
HGNC ID
HGNC:1319
HGNC
Ensembl
ENSG00000171860
NCBI Gene
Aliases
AZ3B, C3AR, HNFAG09
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q16581C3a anaphylatoxin chemotactic receptor48219Ensembl, GeneID, HGNC

Source UniProt

Patents56

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-293674Q16581Espacenet
EP 4641202 A22025-10-29211Q16581Espacenet
JP 2025529142 A2025-09-04659Q16581Espacenet
JP 2025122662 A2025-08-213Q16581Espacenet
WO 2025166319 A12025-08-071Q16581Espacenet
US 12371689 B22025-07-29659Q16581Espacenet
JP 2025517969 A2025-06-123674Q16581Espacenet
KR 1020250017231 A2025-02-04211Q16581Espacenet
US 12006548 B22024-06-11327Q16581Espacenet
JP 2023153821 A2023-10-1829Q16581Espacenet

1 to 10 of 56

See all 56 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,507

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleC3AR1 papersNewest fiscal year
ZIAHL006223The role of the intracellular complement system - the complosome - in Th1 biology162025
ZIADK075149Unravelling immunoregulatory circuits of tissue inflammation82025
P30CA016672Cancer Center Support Grant72025
R01AR051749Complement in the Pathogenesis of Autoimmune Arthritis72025
ZIAHL006222The role of the intracellular complement system - the complosome - in monocytes62025
P30AR073752Washington University Rheumatic Diseases Research Resource-based Center52025
P30CA008748Cancer Center Support Grant42025
P30CA091842Cancer Center Support Grant42025
R01DK076690Complement-mediated injury of the kidney: New mechanisms and novel therapies42025
T32HL007317Principles in Pulmonary Research42025

1 to 10 of 1,507Source NIH's project files

See all 1,507 nih grants

Papers2,264

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Complement Proteins C1q-C5 as Context‑Dependent Regulators of Osteoblast Function and Fracture Healing: A Systematic Review.Orthop Rev (Pavia)202642812634PubTator, text miningPubMed
Spatial analysis reveals cellular microenvironments and mechanisms of inflammation and injury in acute interstitial nephritis.Nat Commun202642802277PubTator, text miningPubMed
High Glucose Induces Biomolecular Dysregulation in Primary Human Corneal Epithelial Cells: Potential Biomarkers of Hyperglycemia-Driven Corneal Impairment.Int J Mol Sci202642794833PubTator, text miningPubMed
Canonical complement C3a-C3AR1 signalling in ageing and age-related disease: Cellular mechanisms, tissue-specific effects and translational challenges.Ageing Res Rev202642716442PubTator, text miningPubMed
Complement receptor C3aR marks heterogeneous tumor-associated macrophage states associated with improved survival in IDH-wildtype glioblastoma.Brain Pathol202642669809PubTator, text miningPubMed
The complement system in the pathophysiology and treatment of depression: From synaptic pruning to pharmacological targeting.Pharmacol Res202642668072PubTator, text miningPubMed
Integrated Bulk and Single-Cell Transcriptomics Reveals the C3-C3AR1 Axis as a Candidate Mediator of Coagulome-Immune Crosstalk in Osteosarcoma.Biomedicines202642652069PubTator, text miningPubMed
Microglia-astrocyte crosstalk as a key organizing principle of Alzheimer's disease: from homeostatic cooperation to maladaptive signaling loops.Front Aging Neurosci202642614559PubTator, text miningPubMed
Maternal Stress Primes Adolescent Stress Susceptibility via Microglial Complement-Dependent Synaptic Phagocytosis.Research (Wash D C)202642558706PubTator, text miningPubMed
Tumor cell-released autophagosome (TRAP) programs inflammatory CAFs to drive the immune-excluded TIME through C3a.Cell Mol Immunol202642527662PubTator, text miningPubMed

1 to 10 of 2,264

See all 2,264 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/719

GET https://conductscience.org/api/genes/v1/719/patents?page=2