Gene · 719
C3AR1: complement C3a receptor 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. C3AR1: complement C3a receptor 1. Genes, record 719. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/719
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q16581 | C3a anaphylatoxin chemotactic receptor | 482 | 19 | Ensembl, GeneID, HGNC |
Source UniProt
Patents56
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4641201 A2 | 2025-10-29 | 3674 | Q16581 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 211 | Q16581 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 659 | Q16581 | Espacenet |
| JP 2025122662 A | 2025-08-21 | 3 | Q16581 | Espacenet |
| WO 2025166319 A1 | 2025-08-07 | 1 | Q16581 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 659 | Q16581 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 3674 | Q16581 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 211 | Q16581 | Espacenet |
| US 12006548 B2 | 2024-06-11 | 327 | Q16581 | Espacenet |
| JP 2023153821 A | 2023-10-18 | 29 | Q16581 | Espacenet |
1 to 10 of 56
See all 56 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,507
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | C3AR1 papers | Newest fiscal year |
|---|---|---|---|
| ZIAHL006223 | The role of the intracellular complement system - the complosome - in Th1 biology | 16 | 2025 |
| ZIADK075149 | Unravelling immunoregulatory circuits of tissue inflammation | 8 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 7 | 2025 |
| R01AR051749 | Complement in the Pathogenesis of Autoimmune Arthritis | 7 | 2025 |
| ZIAHL006222 | The role of the intracellular complement system - the complosome - in monocytes | 6 | 2025 |
| P30AR073752 | Washington University Rheumatic Diseases Research Resource-based Center | 5 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 4 | 2025 |
| P30CA091842 | Cancer Center Support Grant | 4 | 2025 |
| R01DK076690 | Complement-mediated injury of the kidney: New mechanisms and novel therapies | 4 | 2025 |
| T32HL007317 | Principles in Pulmonary Research | 4 | 2025 |
1 to 10 of 1,507Source NIH's project files
See all 1,507 nih grantsPapers2,264
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Complement Proteins C1q-C5 as Context‑Dependent Regulators of Osteoblast Function and Fracture Healing: A Systematic Review. | Orthop Rev (Pavia) | 2026 | 42812634 | PubTator, text mining | PubMed |
| Spatial analysis reveals cellular microenvironments and mechanisms of inflammation and injury in acute interstitial nephritis. | Nat Commun | 2026 | 42802277 | PubTator, text mining | PubMed |
| High Glucose Induces Biomolecular Dysregulation in Primary Human Corneal Epithelial Cells: Potential Biomarkers of Hyperglycemia-Driven Corneal Impairment. | Int J Mol Sci | 2026 | 42794833 | PubTator, text mining | PubMed |
| Canonical complement C3a-C3AR1 signalling in ageing and age-related disease: Cellular mechanisms, tissue-specific effects and translational challenges. | Ageing Res Rev | 2026 | 42716442 | PubTator, text mining | PubMed |
| Complement receptor C3aR marks heterogeneous tumor-associated macrophage states associated with improved survival in IDH-wildtype glioblastoma. | Brain Pathol | 2026 | 42669809 | PubTator, text mining | PubMed |
| The complement system in the pathophysiology and treatment of depression: From synaptic pruning to pharmacological targeting. | Pharmacol Res | 2026 | 42668072 | PubTator, text mining | PubMed |
| Integrated Bulk and Single-Cell Transcriptomics Reveals the C3-C3AR1 Axis as a Candidate Mediator of Coagulome-Immune Crosstalk in Osteosarcoma. | Biomedicines | 2026 | 42652069 | PubTator, text mining | PubMed |
| Microglia-astrocyte crosstalk as a key organizing principle of Alzheimer's disease: from homeostatic cooperation to maladaptive signaling loops. | Front Aging Neurosci | 2026 | 42614559 | PubTator, text mining | PubMed |
| Maternal Stress Primes Adolescent Stress Susceptibility via Microglial Complement-Dependent Synaptic Phagocytosis. | Research (Wash D C) | 2026 | 42558706 | PubTator, text mining | PubMed |
| Tumor cell-released autophagosome (TRAP) programs inflammatory CAFs to drive the immune-excluded TIME through C3a. | Cell Mol Immunol | 2026 | 42527662 | PubTator, text mining | PubMed |
1 to 10 of 2,264
See all 2,264 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/719
GET https://conductscience.org/api/genes/v1/719/patents?page=2