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TRH: thyrotropin releasing hormone

1 protein, 32 patents, 0 drugs, 0 trials, 1,817 NIH grants and 7,228 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTRHHGNC
Namethyrotropin releasing hormoneHGNC
NCBI Gene ID7200NCBI Gene
HGNC IDHGNC:12298HGNC
EnsemblENSG00000170893NCBI Gene
AliasesPro-TRH, TRFNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P20396Pro-thyrotropin-releasing hormone2420Ensembl, GeneID, HGNCUniProt

Patents 32

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1467107P20396Espacenet
EP 4650780 A22025-11-194214P20396Espacenet
JP 2025147176 A2025-10-0613745P20396Espacenet
JP 2025529142 A2025-09-047968P20396Espacenet
US 12371689 B22025-07-297968P20396Espacenet
JP 2025517970 A2025-06-124214P20396Espacenet
JP 2025028160 A2025-02-2813745P20396Espacenet
KR 1020250010750 A2025-01-2113745P20396Espacenet
JP 2024109657 A2024-08-1413752P20396Espacenet
US 11446398 B22022-09-2088857P20396Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 1817

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
ZIAHD000195Intracellular Signaling In Endocrine Cells82,025NIH's project files
P30DK072476Pennington/Louisiana NORC62,025NIH's project files
P30CA008748Cancer Center Support Grant52,025NIH's project files
P30CA056036Translational Research in Cancer52,025NIH's project files
R01DK077148Metabolic and xenobiotic control of thyroid hormone metabolism52,025NIH's project files
R01DK015070Thyroid Physiology Studies of Inherited Disorders42,025NIH's project files
I01BX004293CYP11A1-derived secosteroids as therapeutic agents in UVB induced skin cancer32,025NIH's project files
P30CA016672Cancer Center Support Grant32,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)32,025NIH's project files
R01AR073004Mechanism of action and function of novel secosteroid 20(OH)D3 in the skin32,025NIH's project files

Papers 7228

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42723213PubTator, text miningPubMed
42634546PubTator, text miningPubMed
42622758PubTator, text miningPubMed
42439540PubTator, text miningPubMed
42400203PubTator, text miningPubMed
42384227PubTator, text miningPubMed
42376980PubTator, text miningPubMed
42276064PubTator, text miningPubMed
42270397PubTator, text miningPubMed
42259293PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license