Gene · 7204
TRIO: trio Rho guanine nucleotide exchange factor
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TRIO: trio Rho guanine nucleotide exchange factor. Genes, record 7204. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7204
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O75962 | Triple functional domain protein | 3,097 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents43
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 68228 | O75962 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 6420 | O75962 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 919 | O75962 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 6169 | O75962 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 13760 | O75962 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 7971 | O75962 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 7971 | O75962 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 919 | O75962 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 6169 | O75962 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 6420 | O75962 | Espacenet |
1 to 10 of 43
See all 43 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,388
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TRIO papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 6 | 2025 |
| P40OD010440 | Caenorhabditis Genetics Center | 6 | 2025 |
| R01MH101221 | Rare Mutations and Autism Spectrum Disorders | 6 | 2025 |
| ZIANS003140 | Regulation of Neuroligins and Effects on Synapse Number and Function | 5 | 2025 |
| P30CA013330 | Cancer Center Support Grant | 4 | 2025 |
| P30EY016665 | Core Grant for Vision Research | 4 | 2025 |
| R01MH071316 | Rac-GEF signaling in dendritic spines | 4 | 2025 |
| T32HG000035 | Interdisciplinary Training in Genome Sciences | 4 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 3 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,388Source NIH's project files
See all 1,388 nih grantsPapers1,372
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Wiring the developing brain: The Rho GTPase signaling network in neurodevelopmental disorders. | Neurobiol Dis | 2026 | 42763024 | PubTator, text mining | PubMed |
| MNV-aware molecular characterization of a rare homozygous TTPA complex allele in ataxia with vitamin E deficiency. | Mol Genet Genomics | 2026 | 42711446 | PubTator, text mining | PubMed |
Calcium Channel Subunit Alpha2delta 2 Is Upregulated During Odontoblast-Like Differentiation and Exhibits Higher Basal Expression in Stem Cells From Exfoliated Deciduous Teeth Than in Dental Pulp Stem Cells. | Cureus | 2026 | 42669006 | PubTator, text mining | PubMed |
| An Integrated Proteomics and Genomics Approach to Identify Essential Protein Kinases During Human Trophoblast Development. | FASEB J | 2026 | 42667124 | PubTator, text mining | PubMed |
| Intracellular Retinoid-Binding Proteins (CRBP, CRALBP, CRABP) as Emerging Drug Targets in Retinal Disease. | Int J Mol Sci | 2026 | 42653100 | PubTator, text mining | PubMed |
| An Atomistic Description of Heterotypic Lipid Exchange by Sec14-like Phosphatidylinositol Transfer Proteins. | bioRxiv | 2026 | 42539191 | PubTator, text mining | PubMed |
| An Integrated Proteomics and Genomics Approach to Identify Essential Protein Kinases During Human Trophoblast Development. | bioRxiv | 2026 | 42539170 | PubTator, text mining | PubMed |
| Identification and growth features of developmental delay with macrocephaly caused by a novel TRIO variant affecting the second SH3 domain. | BMC Med Genomics | 2026 | 42421094 | PubTator, text mining | PubMed |
| Ion Channel-Rho GTPase Coupling in Human Odontogenesis: Integrative Structural and Network Dissection of TRIO and CACNA2D2 Variants From Familial Tooth Agenesis. | Cureus | 2026 | 42359198 | PubTator, text mining | PubMed |
| Familial Tooth Agenesis in Lebanese Patients: Clinical Characterization and Whole-Exome Identification of Rare CACNA2D2 and TRIO Variants. | Cureus | 2026 | 42255799 | PubTator, text mining | PubMed |
1 to 10 of 1,372
See all 1,372 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/7204
GET https://conductscience.org/api/genes/v1/7204/patents?page=2