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Gene · 722

C4BPA: complement component 4 binding protein alpha

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. C4BPA: complement component 4 binding protein alpha. Genes, record 722. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/722

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Gene

Symbol
C4BPA
HGNC
Name
complement component 4 binding protein alpha
HGNC
NCBI Gene ID
722
NCBI Gene
HGNC ID
HGNC:1325
HGNC
Ensembl
ENSG00000123838
NCBI Gene
Aliases
C4BP, PRP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P04003C4b-binding protein alpha chain5979Ensembl, GeneID, HGNC

Source UniProt

Patents97

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1442060P04003Espacenet
WO 2025262255 A12025-12-2628P04003Espacenet
EP 4650780 A22025-11-198167P04003Espacenet
EP 4641201 A22025-10-298324P04003Espacenet
JP 2025147176 A2025-10-061905P04003Espacenet
JP 2025529142 A2025-09-045687P04003Espacenet
WO 2025184411 A12025-09-04642P04003Espacenet
US 12371689 B22025-07-295687P04003Espacenet
EP 4587839 A22025-07-2352P04003Espacenet
EP 4582098 A22025-07-091402P04003Espacenet

1 to 10 of 97

See all 97 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,526

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleC4BPA papersNewest fiscal year
R01DK110023C3 Glomerulopathy -- A Collaborative Study62025
T32AR007279Immunobiology of the Rheumatic Diseases62025
P20GM103418Kansas IDeA Network of Biomedical Research Excellence 552025
P30CA016672Cancer Center Support Grant52025
T32AI007046Infectious Diseases Training Program52025
P30CA068485Cancer Center Support Grant42025
R01DK076690Complement-mediated injury of the kidney: New mechanisms and novel therapies42025
ZIAAI001020Host Immune Responses to Antigens of Malaria Parasites42025
ZIAHL006223The role of the intracellular complement system - the complosome - in Th1 biology42025
P30EY008126Core Grant in Vision Research32025

1 to 10 of 1,526Source NIH's project files

See all 1,526 nih grants

Papers2,921

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Treatment-Driven Peripheral Blood Transcriptomic Remodeling and Baseline Predictors of ESSDAI and STAR Response to B Cell Therapy in Sjögren's Disease.Arthritis Rheumatol202642781881PubTator, text miningPubMed
Multi-omics analyses demonstrate complement dysregulation is involved in focal segmental glomerulosclerosis.Front Immunol202642780117PubTator, text miningPubMed
Generation and evaluation of multimers of anti C-reactive protein Nb and alkaline phosphatase based on three self-assembly peptides.Exp Ther Med202642713007PubTator, text miningPubMed
Serum Proteomic Profiling Reveals Renin-Associated Immune and Cytoskeletal Dysregulation in Post-COVID-19 Condition Patients with Secondary Adrenal Insufficiency.J Proteome Res202642695868PubTator, text miningPubMed
Pre-clinical efficacy of a C4BP hexameric IgG Fc fusion protein against Neisseria gonorrhoeae.PLoS One202642640922PubTator, text miningPubMed
Plasma Proteomic Signatures in Alkaptonuria.Biology (Basel)202642589138PubTator, text miningPubMed
DIA-based serum proteomics of the complement-coagulation cascade identifies candidate biomarkers for myasthenia gravis.Front Neurosci202642516550PubTator, text miningPubMed
Association of Endometrial HAND2 Expression with β2-Glycoprotein I Antibodies in Recurrent Pregnancy Loss.Biomedicines202642512033PubTator, text miningPubMed
Glioblastoma immune-related gene landscape and its prognostic significance identified with integrative multiomics.BMC Cancer202642464188PubTator, text miningPubMed
Malondialdehyde epitopes exposed on dying cells are potent modulators of complement activity and efferocytosis.J Lipid Res202642425490PubTator, text miningPubMed

1 to 10 of 2,921

See all 2,921 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/722

GET https://conductscience.org/api/genes/v1/722/patents?page=2