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Gene · 7220

TRPC1: transient receptor potential cation channel subfamily C member 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TRPC1: transient receptor potential cation channel subfamily C member 1. Genes, record 7220. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7220

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Gene

Symbol
TRPC1
HGNC
Name
transient receptor potential cation channel subfamily C member 1
HGNC
NCBI Gene ID
7220
NCBI Gene
HGNC ID
HGNC:12333
HGNC
Ensembl
ENSG00000144935
NCBI Gene
Aliases
HTRP-1, TRP1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P48995Short transient receptor potential channel 17934Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1467590P48995Espacenet
EP 4641201 A22025-10-2916741P48995Espacenet
JP 2025529142 A2025-09-045062P48995Espacenet
US 12371689 B22025-07-295062P48995Espacenet
JP 2025517969 A2025-06-1216741P48995Espacenet
EP 4487869 A22025-01-08482P48995Espacenet
KR 1020240027895 A2024-03-04668P48995Espacenet
JP 2023036863 A2023-03-14668P48995Espacenet
US 11446398 B22022-09-2090281P48995Espacenet
JP 2022524081 A2022-04-27193252P48995Espacenet

1 to 10 of 28

See all 28 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,425

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTRPC1 papersNewest fiscal year
ZIADE000438Molecular Mechanisms Regulating Calcium Flux In Salivary Glands542025
R01DE017102TRPC1, Calcium, and Saliva Secretion452025
R01DK057819Intestinal Mucosal Growth in Health and Surgical Diseases112025
P20GM113123Center for Excellence in Host Pathogen Interactions102025
P30EY014800University of Utah Core Vision Research Grant102025
R01EY027920Molecular mechanisms of mechanotransduction in the aqueous outflow pathway82025
T32EY024234Vision Research Training Grant at the University of Utah82025
R01HL045638Programming of PMN host-defense function during transendothelial migration62025
T32HL007829Training Program in Lung Biology and Pathobiology52025
P20GM103442ND INBRE Health & the Environment42025

1 to 10 of 1,425Source NIH's project files

See all 1,425 nih grants

Papers2,976

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
HINT1 and ARMC10 modulate melanogenesis associated with oxidative stress and mitochondrial dysfunction in melanocytes.Biochim Biophys Acta Mol Cell Res202642810595PubTator, text miningPubMed
Magnetic Mitohormesis as a Potential Non-Invasive Restorative Therapy for X-Linked Muscular Dystrophies.Int J Mol Sci202642737597PubTator, text miningPubMed
Research progress on the role and mechanism of STIM and Orai protein-mediated store-operated calcium entry in cardiovascular diseases.Channels (Austin)202642503223PubTator, text miningPubMed
Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus.Brain Pathol202642373097PubTator, text miningPubMed
The potential mechanisms of exercise-regulated mechanically sensitive ion channels in promoting spinal cord injury repair: a hypothesis-driven narrative review.Rev Neurosci202642370596PubTator, text miningPubMed
Bioprinted human skin equivalent for evaluating non-invasive monopolar radiofrequency treatment: a novel approach.Lasers Med Sci202642268429PubTator, text miningPubMed
Up-Regulation of the TRPM8 Channel Attenuates TRPC1-Mediated Store-Operated Calcium Entry in Abdominal Aortic Aneurysm.Biomolecules202642194089PubTator, text miningPubMed
Correction: Induced TRPC1 expression sensitizes intestinal epithelial cells to apoptosis by inhibiting NF-κB activation through Ca2+ influx.Biochem J202642165259PubTator, text miningPubMed
Implant-derived titanium particles impair macrophage bacterial clearance via TRPC1 and lysosomal dysfunction.PNAS Nexus202641978578PubTator, text miningPubMed
Naturally derived polysaccharides and ganoderic acid A hydrogel with whitening potential to combat oxidative stress and melanin production caused by ultraviolet B.Carbohydr Polym202641943354PubTator, text miningPubMed

1 to 10 of 2,976

See all 2,976 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7220

GET https://conductscience.org/api/genes/v1/7220/patents?page=2