Gene · 7220
TRPC1: transient receptor potential cation channel subfamily C member 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TRPC1: transient receptor potential cation channel subfamily C member 1. Genes, record 7220. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7220
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P48995 | Short transient receptor potential channel 1 | 793 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents28
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 67590 | P48995 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 16741 | P48995 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 5062 | P48995 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 5062 | P48995 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 16741 | P48995 | Espacenet |
| EP 4487869 A2 | 2025-01-08 | 482 | P48995 | Espacenet |
| KR 1020240027895 A | 2024-03-04 | 668 | P48995 | Espacenet |
| JP 2023036863 A | 2023-03-14 | 668 | P48995 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 90281 | P48995 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 193252 | P48995 | Espacenet |
1 to 10 of 28
See all 28 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,425
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TRPC1 papers | Newest fiscal year |
|---|---|---|---|
| ZIADE000438 | Molecular Mechanisms Regulating Calcium Flux In Salivary Glands | 54 | 2025 |
| R01DE017102 | TRPC1, Calcium, and Saliva Secretion | 45 | 2025 |
| R01DK057819 | Intestinal Mucosal Growth in Health and Surgical Diseases | 11 | 2025 |
| P20GM113123 | Center for Excellence in Host Pathogen Interactions | 10 | 2025 |
| P30EY014800 | University of Utah Core Vision Research Grant | 10 | 2025 |
| R01EY027920 | Molecular mechanisms of mechanotransduction in the aqueous outflow pathway | 8 | 2025 |
| T32EY024234 | Vision Research Training Grant at the University of Utah | 8 | 2025 |
| R01HL045638 | Programming of PMN host-defense function during transendothelial migration | 6 | 2025 |
| T32HL007829 | Training Program in Lung Biology and Pathobiology | 5 | 2025 |
| P20GM103442 | ND INBRE Health & the Environment | 4 | 2025 |
1 to 10 of 1,425Source NIH's project files
See all 1,425 nih grantsPapers2,976
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| HINT1 and ARMC10 modulate melanogenesis associated with oxidative stress and mitochondrial dysfunction in melanocytes. | Biochim Biophys Acta Mol Cell Res | 2026 | 42810595 | PubTator, text mining | PubMed |
| Magnetic Mitohormesis as a Potential Non-Invasive Restorative Therapy for X-Linked Muscular Dystrophies. | Int J Mol Sci | 2026 | 42737597 | PubTator, text mining | PubMed |
| Research progress on the role and mechanism of STIM and Orai protein-mediated store-operated calcium entry in cardiovascular diseases. | Channels (Austin) | 2026 | 42503223 | PubTator, text mining | PubMed |
| Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus. | Brain Pathol | 2026 | 42373097 | PubTator, text mining | PubMed |
| The potential mechanisms of exercise-regulated mechanically sensitive ion channels in promoting spinal cord injury repair: a hypothesis-driven narrative review. | Rev Neurosci | 2026 | 42370596 | PubTator, text mining | PubMed |
| Bioprinted human skin equivalent for evaluating non-invasive monopolar radiofrequency treatment: a novel approach. | Lasers Med Sci | 2026 | 42268429 | PubTator, text mining | PubMed |
| Up-Regulation of the TRPM8 Channel Attenuates TRPC1-Mediated Store-Operated Calcium Entry in Abdominal Aortic Aneurysm. | Biomolecules | 2026 | 42194089 | PubTator, text mining | PubMed |
| Correction: Induced TRPC1 expression sensitizes intestinal epithelial cells to apoptosis by inhibiting NF-κB activation through Ca2+ influx. | Biochem J | 2026 | 42165259 | PubTator, text mining | PubMed |
| Implant-derived titanium particles impair macrophage bacterial clearance via TRPC1 and lysosomal dysfunction. | PNAS Nexus | 2026 | 41978578 | PubTator, text mining | PubMed |
| Naturally derived polysaccharides and ganoderic acid A hydrogel with whitening potential to combat oxidative stress and melanin production caused by ultraviolet B. | Carbohydr Polym | 2026 | 41943354 | PubTator, text mining | PubMed |
1 to 10 of 2,976
See all 2,976 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/7220
GET https://conductscience.org/api/genes/v1/7220/patents?page=2