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Gene · 7222

TRPC3: transient receptor potential cation channel subfamily C member 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TRPC3: transient receptor potential cation channel subfamily C member 3. Genes, record 7222. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7222

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Gene

Symbol
TRPC3
HGNC
Name
transient receptor potential cation channel subfamily C member 3
HGNC
NCBI Gene ID
7222
NCBI Gene
HGNC ID
HGNC:12335
HGNC
Ensembl
ENSG00000138741
NCBI Gene
Aliases
SCA41, TRP3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13507Short transient receptor potential channel 392119Ensembl, GeneID, HGNC

Source UniProt

Patents15

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-2910496Q13507Espacenet
JP 2025517969 A2025-06-1210496Q13507Espacenet
JP 2025032204 A2025-03-1137715Q13507Espacenet
EP 4461818 A22024-11-1337715Q13507Espacenet
US 11723347 B22023-08-151Q13507Espacenet
JP 2023058610 A2023-04-2537715Q13507Espacenet
US 11446398 B22022-09-2090284Q13507Espacenet
US 11400116 B22022-08-021434Q13507Espacenet
JP 2022524081 A2022-04-27193255Q13507Espacenet
US 11078247 B22021-08-0312027Q13507Espacenet

1 to 10 of 15

See all 15 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,169

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTRPC3 papersNewest fiscal year
ZIADE000438Molecular Mechanisms Regulating Calcium Flux In Salivary Glands212025
R01DE017102TRPC1, Calcium, and Saliva Secretion172025
R01HL056470Neonatal Modulation of Airway Contractility92025
ZIADE000735Ca2+ signaling and HCO3- secretion by exocrine glands52025
P30EY014800University of Utah Core Vision Research Grant42025
R01CA206573Structure and function of Transient Receptor Potential Channels42025
R01EY027920Molecular mechanisms of mechanotransduction in the aqueous outflow pathway42025
R01HL131517Sex-specific arrhythmogenic mechanisms of atrial fibrillation42025
R01NS100947Inflammatory regulation of epileptogenesis after status epilepticus42025
P20GM113123Center for Excellence in Host Pathogen Interactions32025

1 to 10 of 1,169Source NIH's project files

See all 1,169 nih grants

Papers1,900

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Magnetic Mitohormesis as a Potential Non-Invasive Restorative Therapy for X-Linked Muscular Dystrophies.Int J Mol Sci202642737597PubTator, text miningPubMed
TRPC3-Driven Calcium Microdomains Instruct Peripheral Nerve Regeneration With Protective Implications for Central Neurons.Adv Sci (Weinh)202642640085PubTator, text miningPubMed
TRP matters: a pilot study on expression of mRNA in the parotid glands and their benign tumors.Biochem Biophys Rep202642437085PubTator, text miningPubMed
Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus.Brain Pathol202642373097PubTator, text miningPubMed
A new photochromic sterol controls TRPC3 activity by actuating a hub of regulatory lipid coordination.Eur J Cell Biol202642284743PubTator, text miningPubMed
The non-selective cation channels TRPC3 and TRPC6 in the human carotid body in the elderly.Tissue Cell202642105474PubTator, text miningPubMed
The role of IP3R and TRPC3 channels in vasoconstriction and hypertension.Pflugers Arch202642068376PubTator, text miningPubMed
Functional and structural basis of a hypermorphic TRPC3 variant.Sci Adv202641880503PubTator, text miningPubMed
TrpC5 silencing reduces cell invasion and migration and enhances radiosensitivity in papillary thyroid carcinoma cells.Front Cell Dev Biol202641768995PubTator, text miningPubMed
Lipid Regulation of Mechanosensitive Ion Channels.Int J Mol Sci202641752117PubTator, text miningPubMed

1 to 10 of 1,900

See all 1,900 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

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