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Gene · 7225

TRPC6: transient receptor potential cation channel subfamily C member 6

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TRPC6: transient receptor potential cation channel subfamily C member 6. Genes, record 7225. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7225

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Gene

Symbol
TRPC6
HGNC
Name
transient receptor potential cation channel subfamily C member 6
HGNC
NCBI Gene ID
7225
NCBI Gene
HGNC ID
HGNC:12338
HGNC
Ensembl
ENSG00000137672
NCBI Gene
Aliases
FSGS2, TRP6
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9Y210Short transient receptor potential channel 69316Ensembl, GeneID, HGNC

Source UniProt

Patents40

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1467606Q9Y210Espacenet
EP 4641201 A22025-10-296340Q9Y210Espacenet
JP 2025529142 A2025-09-045066Q9Y210Espacenet
US 12371689 B22025-07-295066Q9Y210Espacenet
JP 2025517969 A2025-06-126340Q9Y210Espacenet
JP 2025032204 A2025-03-1137720Q9Y210Espacenet
EP 4461818 A22024-11-1337720Q9Y210Espacenet
JP 2023058610 A2023-04-2537720Q9Y210Espacenet
US 11446398 B22022-09-2090300Q9Y210Espacenet
JP 2022135162 A2022-09-151Q9Y210Espacenet

1 to 10 of 40

See all 40 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,572

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTRPC6 papersNewest fiscal year
ZIADE000438Molecular Mechanisms Regulating Calcium Flux In Salivary Glands142025
R01DE017102TRPC1, Calcium, and Saliva Secretion102025
I01BX004024Transport and metabolism in the kidney92025
R01DK095045Molecular mechanisms of podocyte injury in FSGS52025
R01CA206573Structure and function of Transient Receptor Potential Channels42025
R01DK099465Mechanisms of disrupted homeostasis and kidney injury42025
R01DK104753Crosstalk Between Lipid Droplets and Other Organelles in Podocytes42025
R01HL056470Neonatal Modulation of Airway Contractility42025
T32HL007227Pathophysiology of Myocardial Disease42025
I01BX005823Endothelial Healing is Inhibited by Activation of TRPC6 Channels32025

1 to 10 of 1,572Source NIH's project files

See all 1,572 nih grants

Papers2,972

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
βKlotho filters ligand-independent FGFR1/4-PLCγ signaling to prevent aberrant constitutive Ca2+ entry.Korean J Physiol Pharmacol202642825310PubTator, text miningPubMed
Reciprocal Coupling among Extracellular Matrix Mechanics, Mechanosensitive Ion Channels, and Cell Remodeling Behaviors.ACS Appl Mater Interfaces202642675897PubTator, text miningPubMed
A novel TRPC6 variant (c.131C>T, p.(Pro44Leu)) associated with focal segmental glomerulosclerosis: a case report.Front Genet202642634699PubTator, text miningPubMed
Integrative Genome-Wide Association Study with eQTL Combined with Transcriptome Analysis Reveals SLC18A1 as a Novel Biomarker for Small Cell Lung Cancer.Curr Med Chem202642634329PubTator, text miningPubMed
Mechanisms and Current Therapeutic Targets of Podocyte Damage in Diabetic Kidney Disease.Curr Diabetes Rev202642613708PubTator, text miningPubMed
Pharmacological inhibition of store-operated calcium entry enhances sorafenib-induced antitumor effects in Huh7 hepatocellular carcinoma cells.Cancer Chemother Pharmacol202642581130PubTator, text miningPubMed
Phosgene inhalation injury in mice: Modeling human pathophysiology, biomarker discovery, and therapeutic target identification.Toxicol Appl Pharmacol202642575345PubTator, text miningPubMed
The dual role of ion channels in diabetic kidney disease: a translational paradigm for biomarkers and target discovery - reviews and prospects.Am J Transl Res202642491139PubTator, text miningPubMed
TRPC6-mediated calcium signaling is involved in T2DM-induced hepatic steatosis and fibrosis and the modulation of ginsenoside Rg1.J Pharmacol Sci202642481130PubTator, text miningPubMed
Proteomic Analyses of Early Versus Advanced Primary Open-Angle Glaucoma Uncover Biochemical Signatures Associated With Disease Staging.Mol Cell Proteomics202642468813PubTator, text miningPubMed

1 to 10 of 2,972

See all 2,972 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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