Gene · 7225
TRPC6: transient receptor potential cation channel subfamily C member 6
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TRPC6: transient receptor potential cation channel subfamily C member 6. Genes, record 7225. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7225
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9Y210 | Short transient receptor potential channel 6 | 931 | 6 | Ensembl, GeneID, HGNC |
Source UniProt
Patents40
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 67606 | Q9Y210 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 6340 | Q9Y210 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 5066 | Q9Y210 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 5066 | Q9Y210 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 6340 | Q9Y210 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 37720 | Q9Y210 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 37720 | Q9Y210 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 37720 | Q9Y210 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 90300 | Q9Y210 | Espacenet |
| JP 2022135162 A | 2022-09-15 | 1 | Q9Y210 | Espacenet |
1 to 10 of 40
See all 40 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,572
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TRPC6 papers | Newest fiscal year |
|---|---|---|---|
| ZIADE000438 | Molecular Mechanisms Regulating Calcium Flux In Salivary Glands | 14 | 2025 |
| R01DE017102 | TRPC1, Calcium, and Saliva Secretion | 10 | 2025 |
| I01BX004024 | Transport and metabolism in the kidney | 9 | 2025 |
| R01DK095045 | Molecular mechanisms of podocyte injury in FSGS | 5 | 2025 |
| R01CA206573 | Structure and function of Transient Receptor Potential Channels | 4 | 2025 |
| R01DK099465 | Mechanisms of disrupted homeostasis and kidney injury | 4 | 2025 |
| R01DK104753 | Crosstalk Between Lipid Droplets and Other Organelles in Podocytes | 4 | 2025 |
| R01HL056470 | Neonatal Modulation of Airway Contractility | 4 | 2025 |
| T32HL007227 | Pathophysiology of Myocardial Disease | 4 | 2025 |
| I01BX005823 | Endothelial Healing is Inhibited by Activation of TRPC6 Channels | 3 | 2025 |
1 to 10 of 1,572Source NIH's project files
See all 1,572 nih grantsPapers2,972
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| βKlotho filters ligand-independent FGFR1/4-PLCγ signaling to prevent aberrant constitutive Ca2+ entry. | Korean J Physiol Pharmacol | 2026 | 42825310 | PubTator, text mining | PubMed |
| Reciprocal Coupling among Extracellular Matrix Mechanics, Mechanosensitive Ion Channels, and Cell Remodeling Behaviors. | ACS Appl Mater Interfaces | 2026 | 42675897 | PubTator, text mining | PubMed |
| A novel TRPC6 variant (c.131C>T, p.(Pro44Leu)) associated with focal segmental glomerulosclerosis: a case report. | Front Genet | 2026 | 42634699 | PubTator, text mining | PubMed |
| Integrative Genome-Wide Association Study with eQTL Combined with Transcriptome Analysis Reveals SLC18A1 as a Novel Biomarker for Small Cell Lung Cancer. | Curr Med Chem | 2026 | 42634329 | PubTator, text mining | PubMed |
| Mechanisms and Current Therapeutic Targets of Podocyte Damage in Diabetic Kidney Disease. | Curr Diabetes Rev | 2026 | 42613708 | PubTator, text mining | PubMed |
| Pharmacological inhibition of store-operated calcium entry enhances sorafenib-induced antitumor effects in Huh7 hepatocellular carcinoma cells. | Cancer Chemother Pharmacol | 2026 | 42581130 | PubTator, text mining | PubMed |
| Phosgene inhalation injury in mice: Modeling human pathophysiology, biomarker discovery, and therapeutic target identification. | Toxicol Appl Pharmacol | 2026 | 42575345 | PubTator, text mining | PubMed |
| The dual role of ion channels in diabetic kidney disease: a translational paradigm for biomarkers and target discovery - reviews and prospects. | Am J Transl Res | 2026 | 42491139 | PubTator, text mining | PubMed |
| TRPC6-mediated calcium signaling is involved in T2DM-induced hepatic steatosis and fibrosis and the modulation of ginsenoside Rg1. | J Pharmacol Sci | 2026 | 42481130 | PubTator, text mining | PubMed |
| Proteomic Analyses of Early Versus Advanced Primary Open-Angle Glaucoma Uncover Biochemical Signatures Associated With Disease Staging. | Mol Cell Proteomics | 2026 | 42468813 | PubTator, text mining | PubMed |
1 to 10 of 2,972
See all 2,972 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/7225
GET https://conductscience.org/api/genes/v1/7225/patents?page=2