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TSC2: TSC complex subunit 2

1 protein, 61 patents, 0 drugs, 0 trials, 6,136 NIH grants and 12,244 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTSC2HGNC
NameTSC complex subunit 2HGNC
NCBI Gene ID7249NCBI Gene
HGNC IDHGNC:12363HGNC
EnsemblENSG00000103197NCBI Gene
AliasesLAM, PPP1R160, TSC4, tuberinNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P49815Tuberin1,8072Ensembl, GeneID, HGNCUniProt

Patents 61

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026517182 A2026-05-281P49815Espacenet
JP 2026067851 A2026-04-21386P49815Espacenet
EP 4688004 A22026-02-111P49815Espacenet
EP 4650780 A22025-11-19453P49815Espacenet
EP 4640832 A22025-10-295P49815Espacenet
EP 4641201 A22025-10-29313P49815Espacenet
JP 2025529142 A2025-09-045084P49815Espacenet
US 12371689 B22025-07-295084P49815Espacenet
JP 2025517969 A2025-06-12313P49815Espacenet
JP 2025517970 A2025-06-12453P49815Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 6136

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1902,025NIH's project files
P30CA008748Cancer Center Support Grant1422,025NIH's project files
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes1022,025NIH's project files
ZIAHL002541Characterization of the Pathogenesis of Lymphangioleiomyomatosis (LAM)572,025NIH's project files
P30CA006973Regional Oncology Research Center282,025NIH's project files
U54NS092090Developmental Synaptopathies Associated with TSC, PTEN, SHANK3 and SynGAP1 Pathogenic Variants272,025NIH's project files
ZIABC011028Clinical Studies of the Molecular Genetic Basis of Kidney Cancer242,025NIH's project files
ZIDBC011089Clinical Nursing and Data Management Core232,025NIH's project files
ZIABC011038Molecular Therapeutics of Kidney Cancer: VHL Gene and Fumarate Hydratase Gene222,025NIH's project files
ZIABC011043Molecular Therapeutics of Kidney Cancer: MET Gene and BHD Gene202,025NIH's project files

Papers 12244

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42818507PubTator, text miningPubMed
42811030PubTator, text miningPubMed
42808379PubTator, text miningPubMed
42794433PubTator, text miningPubMed
42778607PubTator, text miningPubMed
42762881PubTator, text miningPubMed
42749428PubTator, text miningPubMed
42747551PubTator, text miningPubMed
42743758PubTator, text miningPubMed
42739200PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license