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TSHR: thyroid stimulating hormone receptor

1 protein, 62 patents, 2 drugs, 10 trials, 1,511 NIH grants and 10,267 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTSHRHGNC
Namethyroid stimulating hormone receptorHGNC
NCBI Gene ID7253NCBI Gene
HGNC IDHGNC:12373HGNC
EnsemblENSG00000165409NCBI Gene
AliasesCHNG1, LGR3, hTSHR-INCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P16473Thyrotropin receptor7649Ensembl, GeneID, HGNCUniProt

Patents 62

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4796563 A12026-08-265P16473Espacenet
EP 4745230 A22026-05-2027P16473Espacenet
JP 2026004568 A2026-01-1467098P16473Espacenet
JP 2026004568 A2026-01-1467101P16473Espacenet
WO 2025259600 A22025-12-188P16473Espacenet
EP 4641201 A22025-10-293433P16473Espacenet
JP 2025147176 A2025-10-0613770P16473Espacenet
JP 2025147176 A2025-10-0613771P16473Espacenet
WO 2025207934 A12025-10-021P16473Espacenet
KR 1020250107308 A2025-07-142P16473Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
THYROTROPINCHEMBL1201532Thyroid stimulating hormone receptor agonistAGONISTChEMBL
THYROTROPIN ALFACHEMBL1201533Thyroid stimulating hormone receptor agonistAGONISTChEMBL

Trials 10

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04447183THYROTROPIN ALFAPHASE2ClinicalTrials.gov
NCT02145143THYROTROPIN ALFAEARLY_PHASE1ClinicalTrials.gov
NCT01736163THYROTROPIN ALFAClinicalTrials.gov
NCT01403324THYROTROPINClinicalTrials.gov
NCT01403324THYROTROPIN ALFAClinicalTrials.gov
NCT00435851THYROTROPINPHASE3ClinicalTrials.gov
NCT00415233THYROTROPINPHASE3ClinicalTrials.gov
NCT00295763THYROTROPIN ALFAPHASE3ClinicalTrials.gov
NCT00196729THYROTROPIN ALFAPHASE3ClinicalTrials.gov
NCT00145366THYROTROPINPHASE2ClinicalTrials.gov

NIH grants 1511

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01DK015070Thyroid Physiology Studies of Inherited Disorders282,025NIH's project files
P30CA008748Cancer Center Support Grant272,025NIH's project files
P30EY007003University of Michigan Vision Research Center252,025NIH's project files
R01DK067555Analyzing Genes for Autoimmune Thyroiditis and Diabetes: Translation to Therapy192,025NIH's project files
I01BX000800TSH Receptor Autoregulation72,025NIH's project files
P30CA016672Cancer Center Support Grant62,025NIH's project files
P30AG024827Pittsburgh Older Americans Independence Center42,025NIH's project files
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant42,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)42,025NIH's project files
P30DK020595Diabetes Research and Training Center42,025NIH's project files

Papers 10267

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42823791PubTator, text miningPubMed
42814798PubTator, text miningPubMed
42808110PubTator, text miningPubMed
42797068PubTator, text miningPubMed
42790002PubTator, text miningPubMed
42777370PubTator, text miningPubMed
42776255PubTator, text miningPubMed
42775116PubTator, text miningPubMed
42773785PubTator, text miningPubMed
42760102PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license