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C5: complement C5

1 protein, 264 patents, 13 drugs, 191 trials, 2,343 NIH grants and 6,133 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolC5HGNC
Namecomplement C5HGNC
NCBI Gene ID727NCBI Gene
HGNC IDHGNC:1331HGNC
EnsemblENSG00000106804NCBI Gene
AliasesC5D, C5a, C5b, CPAMD4, ECLZBNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P01031Complement C51,67643Ensembl, GeneID, HGNCUniProt

Patents 264

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4830719 A22026-10-2824P01031Espacenet
JP 2026090361 A2026-06-0224P01031Espacenet
JP 2026088141 A2026-05-28207P01031Espacenet
JP 2026057572 A2026-04-02362P01031Espacenet
EP 4716544 A22026-04-01175P01031Espacenet
JP 2026004568 A2026-01-1442090P01031Espacenet
EP 4667578 A22025-12-24192P01031Espacenet
EP 4667578 A22025-12-24195P01031Espacenet
EP 4667578 A22025-12-24314P01031Espacenet
EP 4650780 A22025-11-19605P01031Espacenet

Drugs 13

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AVACINCAPTAD PEGOL SODIUMCHEMBL4297889Complement C5 inhibitorINHIBITORChEMBL
CEMDISIRANCHEMBL4297722Complement C5 mRNA RNAi inhibitorRNAI INHIBITORChEMBL
CROVALIMABCHEMBL4594316Complement C5 inhibitorINHIBITORChEMBL
ECULIZUMABCHEMBL1201828Complement C5 inhibitorINHIBITORChEMBL
NOMACOPANCHEMBL4297928Complement C5 inhibitorINHIBITORChEMBL
OLENDALIZUMABCHEMBL3990025Complement C5 inhibitorINHIBITORChEMBL
PEXELIZUMABCHEMBL2107979Complement C5 inhibitorINHIBITORChEMBL
POZELIMABCHEMBL4298086Complement C5 inhibitorINHIBITORChEMBL
RAVULIZUMABCHEMBL3989986Complement C5 inhibitorINHIBITORChEMBL
TESIDOLUMABCHEMBL4298012Complement C5 binding agentBINDING AGENTChEMBL

Trials 191

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07557420RAVULIZUMABPHASE3ClinicalTrials.gov
NCT07519005ECULIZUMABEARLY_PHASE1ClinicalTrials.gov
NCT07420296ECULIZUMABPHASE3ClinicalTrials.gov
NCT07399730RAVULIZUMABClinicalTrials.gov
NCT07230834POZELIMABPHASE1ClinicalTrials.gov
NCT07215949ZILUCOPLANPHASE3ClinicalTrials.gov
NCT07184840ECULIZUMABPHASE2ClinicalTrials.gov
NCT07177859ECULIZUMABPHASE3ClinicalTrials.gov
NCT07172022CROVALIMABPHASE2ClinicalTrials.gov
NCT07154745CEMDISIRANPHASE3ClinicalTrials.gov

NIH grants 2343

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
ZIAHL006223The role of the intracellular complement system - the complosome - in Th1 biology132,025NIH's project files
R01AR051749Complement in the Pathogenesis of Autoimmune Arthritis122,025NIH's project files
R01DK110023C3 Glomerulopathy -- A Collaborative Study92,025NIH's project files
ZIADK075149Unravelling immunoregulatory circuits of tissue inflammation92,025NIH's project files
ZIAHL006222The role of the intracellular complement system - the complosome - in monocytes82,025NIH's project files
R01DK076690Complement-mediated injury of the kidney: New mechanisms and novel therapies72,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award72,025NIH's project files
P30CA036727Buffett Cancer Center Support Grant62,025NIH's project files
T32HL007317Principles in Pulmonary Research52,025NIH's project files
P20GM103418Kansas IDeA Network of Biomedical Research Excellence 542,025NIH's project files

Papers 6133

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42812414PubTator, text miningPubMed
42717567PubTator, text miningPubMed
42697106PubTator, text miningPubMed
42694628PubTator, text miningPubMed
42687818PubTator, text miningPubMed
42685900PubTator, text miningPubMed
42596551PubTator, text miningPubMed
42507440PubTator, text miningPubMed
42481362PubTator, text miningPubMed
42441931PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license